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Streptozocin

Latest prescription information about Streptozocin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Streptozocin
Pronunciation : strep toe zoe' sin
Therapeutic Classification : Chemotherapy
Trade Name(s): 
International- Zanosar.
Why it is prescribed (Indications) : 
This medication is an alkylating agent (chemotherapy drug), prescribed for pancreatic cancer. It stops the growth of cancer cells. 
When it is not to be taken (Contraindications): 
Contraindicated in pregnancy and lactation; known hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV: The recommended dose is 500 mg/day/m2 of body surface area for five consecutive days every six weeks.
How it should be taken : It comes as a solution for injection, administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver or kidney disease and diabetes.
* It may affect menstrual cycle in women, and stop sperm production in men.
* Avoid vaccination while taking this medication.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Gastrointestinal- Diarrhea, nausea and vomiting.
Liver- Elevated liver enzyme level.
Blood- Decrease in leucocytes and platelet count.
Metabolic- Decrease in sugar level.
Genitourinary- Decreased urination.
Central Nervous System- Dizziness, drowsiness, lightheadedness and weakness.
Skin- Rash and itching.
Other Precautions : 
* Avoid alcoholic beverages.
Storage Conditions : 
Store it in refrigerator (2° to 8°C) and protect from light.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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