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Sodium Polystyrene Sulfonate

Latest prescription information about Sodium Polystyrene Sulfonate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Sodium Polystyrene Sulfonate
Pronunciation : SOE-dee-um POL-ee-STYE-reen SUL-foe-nate
Therapeutic Classification : Potassium-removing Resin
Trade Name(s): 
International- Kayexalate, Kionex, SPS.
Other Name : 
Potassium removal Polysterene Sulphonate Resin.
Why it is prescribed (Indications) : 
This medication is a potassium-removing resin, prescribed for hyperkalemia (without ECG changes).  It affects the exchange of sodium and potassium in the body.
When it is not to be taken (Contraindications): Contraindicated in patients with obstructive bowel disease, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Dosage: Adults: PO- The recommended dose is 15 g, 3-4 times daily in water. Children: 0.5- 1 g/kg daily in divided doses.
How it should be taken : 
It comes as a powder to take by mouth, with water.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart or kidney disease, high blood pressure, constipation, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* Monitor blood potassium and other blood electrolyte levels, and electrocardiograms (ECGs) regularly while taking this medication.
Side Effects : 
Gastrointestinal - Rectal ulceration, GI irritation, anorexia, nausea, vomiting, constipation and diarrhea.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store in a dry place below 30°C.
Suspensions of the resin should be freshly prepared and not to be stored beyond 24 hours.


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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