Generic Name : Sodium Oxybate Pronunciation : so-di-um-ox-ih-bate Therapeutic Classification : Central Nervous System Agents
International- Xyrem. Why it is prescribed (Indications) :
This medication is a central nervous system depressant, used to treat daytime sleepiness in patients with narcolepsy, and sudden muscular weakness called cataplexy. When it is not to be taken (Contraindications): Contraindicated in patients being treated with sedative hypnotic agents, patients with succinic semialdehyde dehydrogenase deficiency, and hypersensitivity.
Dosage & When it is to be taken :
PO- The recommended starting dose is 4.5 g/night divided into two equal doses of 2.25 gm. The starting dosage can then be increased to a maximum of 9 g/night in increments of 1.5 g/night (0.75 g per dose). How it should be taken :
It comes as an oral solution to take by mouth. Warnings and Precautions :
*It is a habit forming drug. It is called the street drug of abuse. Therefore it is available only through a special program and the treatment can be carried out only under strict monitoring by a doctor.
*Avoid drinking alcohol, driving and operating machinery.
*Caution should be exercised in patients with history of liver disease, heart disease, high blood pressure, or kidney disease , history of alcohol or drug abuse, asthma, emphysema, or bronchitis, sleep apnea, mental illness such as bipolar disorder or schizophrenia. Side Effects :
Most Common- Headache, nausea, dizziness, throat pain, drowsiness, vomiting, and urinary incontinence.
Eye and ENT- Ringing in the ear, blurred vision.
Gastrointestinal- Abdominal pain, Diarrhea, Indigestion, Nausea and Vomiting.
General- Lethargy, pain.
Musculoskeletal- Back pain.
Central Nervous System- Disturbance in attention, Dizziness, Headache, Confusional state, Depression, Sleep disorder, Sleep walking.
*Avoid excess dosage. Storage Conditions :
Store as per instructions and keep out of reach of children.
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