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Sodium Oxybate

Updated on : December - 2012
Latest prescription information about Sodium Oxybate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Sodium Oxybate
Pronunciation : so-di-um-ox-ih-bate
Therapeutic Classification : Central Nervous System Agents
Trade Name(s): 
International- Xyrem.
Why it is prescribed (Indications) : 
This medication is a central nervous system depressant, used to treat daytime sleepiness in patients with narcolepsy, and sudden muscular weakness called cataplexy. 
When it is not to be taken (Contraindications): Contraindicated in patients being treated with sedative hypnotic agents, patients with succinic semialdehyde dehydrogenase deficiency, and hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
PO- The recommended starting dose is 4.5 g/night divided into two equal doses of 2.25 gm. The starting dosage can then be increased to a maximum of 9 g/night in increments of 1.5 g/night (0.75 g per dose).
How it should be taken : 
It comes as an oral solution to take by mouth.
Warnings and Precautions : 
*It is a habit forming drug. It is called the street drug of abuse. Therefore it is available only through a special program and the treatment can be carried out only under strict monitoring by a doctor.
*Avoid drinking alcohol, driving and operating machinery.
*Caution should be exercised in patients with history of liver disease, heart disease, high blood pressure, or kidney disease , history of alcohol or drug abuse, asthma, emphysema, or bronchitis, sleep apnea, mental illness such as bipolar disorder or schizophrenia.
Side Effects : 
Most Common- Headache, nausea, dizziness, throat pain, drowsiness, vomiting, and urinary incontinence.
Eye and ENT- Ringing in the ear, blurred vision.
Gastrointestinal- Abdominal pain, Diarrhea, Indigestion, Nausea and Vomiting.
General- Lethargy, pain.
Musculoskeletal- Back pain.
Central Nervous System- Disturbance in attention, Dizziness, Headache, Confusional state, Depression, Sleep disorder, Sleep walking.
Other Precautions : 
*Avoid excess dosage.
Storage Conditions : 
Store as per instructions and keep out of reach of children.

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Member Comments ( 1 )
I have fibromyalgia for over 3 years and I've been living in hell, I really want to give this medication GHS a try.
(Posted by katia, Peru Date : 9/17/2008 )

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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