Generic Name : Simvastatin and Sitagliptin Pronunciation : SIM va stat in and SIT a GLIP tin♦ Safety Labeling Changes Approved By FDA
International- Juvisync. Why it is prescribed (Indications) :
This combination medication contains antidiabetic and cholesterol-lowering agent, prescribed for treating type 2 diabetes and lowering high cholesterol. It works by reducing bad cholesterol level and by regulating the levels of insulin. When it is not to be taken (Contraindications): Contraindicated in patients with type 1 diabetes, diabetic ketoacidosis, severe kidney problem, and pregnant and breastfeeding women.
♦It should not be co-administered with CYP3A4 inhibitors.
Dosage & When it is to be taken :
The recommended starting dose is 100-mg/40 mg per day. How it should be taken :
It comes as a tablet to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with history of low blood pressure, kidney problems, low thyroid function, muscle problems or a family history of muscle problems, or serious metabolic, hormonal, or electrolyte problems, seizures, liver problems, or alcohol abuse, angioedema, any allergy, who are taking other medications, elderly, children.
* Follow the diet and exercise program as directed by your physician. Side Effects :
Body as a Whole - Swelling, abdominal pain.
Heart - Abnormal heart rhythm.
Gastrointestinal - Constipation, stomach inflammation.
Metabolic - Diabetes mellitus.
♦ Musculoskeletal - Muscle pain and Immune-mediated necrotizing myopathy (IMNM).
Central Nervous System - Headache, sleeplessness, fainting.
Respiratory - Lung inflammation.
Skin - Eczema.
Genitourinary - Urinary tract infection.
* Avoid excess dosage. Storage Conditions :
Store at 20-25°C.
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