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Simvastatin

Latest prescription information about Simvastatin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Simvastatin
Pronunciation : SIM-va-STAT-in
Therapeutic Classification : antilipemics
Trade Name(s): 
India- Biosim Tab, Sim Tab, Simcard Tab, Simchol Tab, Simlip Film-Coated Tab, Simlo Tab, Simstat Tab, Simstat-N Tab, Simvas Tab, Simvastol Tab, Simvastol-N Tab, Simvax Tab, Simvin Tab, Simvo Tab, Simvofix Tab, Simvotin Fc-Tab, Simvotin Tab, Sin Tab, Starstat Tab, Svt Tab, Vastatin Tab, Zosta Tab.
International- Zocor.
Why it is prescribed (Indications) : 
This medication is an HMG-CoA reductase inhibitor, also known as a "statin", used for lowering high cholesterol and triglycerides in certain patients with appropriate diet. It reduces the risk of cardio vascular diseases, and blood vessels blockage.

When it is not to be taken (Contraindications): 


Contraindicated in patients with hypersensitivity, acute liver disease or unexplained persistent elevations of serum transaminases, during pregnancy and breastfeeding.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.


When it is to be taken : 
The recommended dose is 5-20mg/day by orally. The maximum dose is 40mg/day.
How it should be taken : 
It comes as a tablet to take by mouth (orally). It is usually taken one to three times a day, with or without food. Avoid excessive consumption (> 1 L/day) of grapefruit juice.
Special Instruction : 
* Caution should be exercised patients with history of liver disease.
* It may lead to rapid breakdown of skeletal muscle (rhabdomyolysis), severe infection, low blood pressure, major surgical trauma, uncontrolled seizures or severe metabolic, endocrine and electrolyte disorder.
* Avoid drinking alcohol otherwise it may result in liver failure.
* This medication should be used with extreme caution in children younger than 10 years old and in those who have not reached puberty. Discontinue treatment if there is marked or persistent increase in serum-aminotransferase concentrations.
Side Effects : 
Central Nervous System- Headache, dizziness, sleeplessness, depression.
Gastrointestinal- Nausea, flatulence, distortion of the sense of taste, abdominal pain, diarrhea, constipation.
Eye- Lens opacities, blurring of vision.
Metabolic- Serum transaminases and CPK elevations.
Musculoskeletal- Muscle pain and muscle weakness.
Miscellaneous- Heartburn, hypersensitivity, sexual dysfunction, and upper respiratory symptoms.
Other Precautions : 
*Avoid changing the dose with out doctor's advice.
Storage Conditions : 
Oral: Store at 5-30°C. Store it in an airtight container and keep away from children.

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