Sibutramine - Drug Information

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Last Updated : 9/27/2017

General Information on Sibutramine

Generic Name : Sibutramine

Pronunciation : si-BUE-tra-meen

Latest prescription information about Sibutramine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Appetite Suppressants

Trade Names/Brand Names of Sibutramine

India : 

Overview of Sibutramine

Sibutramine results in weight loss by reducing appetite. As a result, the consumption of food is lowered.

Why is Sibutramine Prescribed? (Indications)

Sibutramine has been banned in several countries including the United States, European countries and India due to its cardiovascular side effects like heart attack and stroke.

Sibutramine is prescribed for the treatment of obesity along with diet restrictions and exercise in patients who suffer from obesity-related conditions like high blood pressure, diabetes and high cholesterol.

Sibutramine works by interfering with the chemicals in the brain called as neurotransmitters (norepinephrine, serotonin, dopamine). It thereby promotes the feeling of satiety (fullness) and a decrease in the appetite, finally resulting in a low intake of food.
 

When should Sibutramine not to be taken? (Contraindications)

Sibutramine should not be used in patients with the following conditions:

Allergy to the drug
Congestive heart failure, serious abnormal heart rhythms, chest pain, episodes of heart attack and stroke
Major eating disorder (anorexia nervosa or bulimia nervosa)
Uncontrolled hypertension
Overactive thyroid
History of depressive or maniac illness
Seizure disorders
Closed angle glaucoma ( increased pressure in the eye resulting in optic nerve damage)
Pheochromocytoma (tumor in the adrenal medulla)
Severe liver damage or kidney damage particularly in patients on dialysis
Along with medications like monoamine oxide inhibitors I (MAO I) or other centrally acting weight loss drugs

What is the dosage of Sibutramine?

The initial recommended dosage for adults is 10mg once daily.
The dosage can be increased to 15mg once a day (only after 4 weeks) particularly in those who do not show a positive response to a low-calorie diet and exercise.
The dose of 5mg is used in patients who do not tolerate with a usual 10mg dose.

How should Sibutramine be taken?

Sibutramine comes as a capsule or tablet to be taken by mouth. It can be taken either with or without food and should be taken in the morning.
Sibutramine should not be used for more than two years.

What are the warnings and precautions for Sibutramine?

Blood pressure and pulse should be checked before starting the sibutramine treatment and should be monitored during the treatment at regular intervals.
Patients should be monitored for symptoms of neuroleptic malignant syndrome which include high body temperature, fluctuation in vital signs, changes in mental state and muscle rigidity.
Dilatation of pupils is reported; therefore sibutramine must not be used or used with extreme caution in patients with narrow-angle glaucoma.
Due to a risk for bleeding, sibutramine should be used with caution in patients with bleeding problems or taking drugs that could result in bleeding.
Patients under sibutramine therapy should not recommend it to other people for its weight loss effect since sibutramine interacts with many drugs and illnesses and should be prescribed on an individual basis.
Patients should be advised to inform their physician before taking some over-the-counter (OTC) medicines such as decongestants, cough syrups and some weight reducing pills while on sibutramine.
Women should inform their physician if they are pregnant/breastfeeding, or planning a pregnancy.

What are the side effects of Sibutramine?

  Gastro intestinal: Dry mouth, nausea, vomiting, indigestion, loss of appetite, constipation, gallstone formation
  Central Nervous System: Insomnia, dizziness, anxiety, depression, drowsiness, sensation of pricking and burning symptoms, headache
  Cardio vascular system: Increased blood pressure, palpitation
  Respiratory: Inflammation of nose, sinuses and throat, shortness of breath, increased coughing
  Genito urinary: Urinary tract infection, painful menstruation with abdominal cramps, abnormal uterus bleeding
  Musculoskeletal: Joint disorder, muscle and joint pain, inflammation of the synovium (the tissue that surrounds tendon), back pain
  Others: Thirst, rashes, acne, problems with vision and speech, allergic reaction

What are the other precautions for Sibutramine?

Sibutramine treatment should only be started at least two weeks after stopping MAOIs such as selegiline, phenelzine and moclobemide.

What are the Drug Interactions of Sibutramine?

Concomitant use of sibutramine with drugs like ketoconazole and erythromycin increases the plasma levels of sibutramine.
Sibutramine taken along with antidepressant drugs such as selegiline and paroxetine, and migraine drugs such as sumatriptan and zolmitriptan can lead to serotonin syndrome (symptoms of high temperature more than 41.1c, agitation, sweating, dilated pupils, seizures and muscle breakdown).
Sibutramine taken along with opioid drugs such as morphine, codeine and hydrocodone also lead to serotonin syndrome.
Other drugs such as lithium, tryptophan, ergot drugs, decongestants and cough syrups can also cause interactions with sibutramine.

What are the storage conditions of Sibutramine?

The capsules and tablets should be stored at a room temperature and kept in an air tight container.
They should be protected from excess light and moisture.

Last Updated : 9/27/2017

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