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Samarium SM 153 Lexdronam

Latest prescription information about Samarium SM 153 Lexdronam. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Samarium SM 153 Lexdronam
Pronunciation : sa-MAR-ee-um Sm 153 lex-ID-roe-nam
Therapeutic Classification : Radiopharmaceutical, Antineoplastic
Trade Name(s): 
International- Quadramet.
Why it is prescribed (Indications) : 
This medication is a radioisotope, prescribed for relieving the bone pain that may occur with confirmed osteoblastic metastatic bone lesions.  
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV- The recommended dose is 1.0 mCi/kg, administered intravenously over a period of one minute.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart failure, irregular heartbeat, kidney impairment, urinary incontinence, bone marrow depression, blood disorders, poor immunity, low blood calcium levels, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* Avoid live immunizations/vaccinations during the treatment period.
* Avoid contact with people who have infections.
* It may reduce platelet counts; avoid injury or bruising.
Side Effects : 
Body as a Whole - Worsening of the condition, fever, chills and infection.
Heart - Abnormal heart rhythm, chest pain and high or low blood pressure.
Gastrointestinal - Abdominal pain, diarrhea, nausea and vomiting.
Blood - Clotting disorder, anemia, decrease in white blood cells, and platelets, lymph node disease, blood in urine and nosebleed.
Musculoskeletal - Muscle pain, weakness and fracture.
Central Nervous System - Dizziness, tingling, spinal cord compression and stroke.
Respiratory - Lung inflammation and increased cough.
Skin - Bruising and rash.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Normally handled and stored by healthcare providers.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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