Generic Name : Romidepsin Pronunciation : ROE-mi-DEP-sin
International- Istodax. Why it is prescribed (Indications) :
This medication is a histone deacetylase (HDAC) inhibitor, prescribed for cutaneous T-cell lymphoma (CTCL) or peripheral T-cell lymphoma (PTCL). It works by slowing the growth of cancer cells. When it is not to be taken (Contraindications): Hypersensitivity.
Dosage & When it is to be taken :
IV- The recommended dose is 14 mg/m˛, over a 4-hour period infusion on days 1, 8 and 15 of a 28-day cycle. How it should be taken :
It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions :
* Caution should be exercised in patients with history of liver or kidney impairment, irregular heartbeat or other heart diseases, nausea, vomiting, or diarrhea, who have undergone chemotherapy, any allergy, during pregnancy and breastfeeding.
* It may reduce platelet counts; avoid injury or bruising.
* Patient may develop with increased risk of tumor lysis syndrome (TLS) with the following symptoms: irregular heartbeat, fainting, decreased urination, muscle weakness or cramps, nausea, vomiting, diarrhea, or loss of appetite. If it is so consult with your doctor.
* Monitor complete blood cell counts, blood electrolyte levels, and electrocardiograms (ECGs) regularly while taking this medication. Side Effects :
Gastrointestinal - Nausea, vomiting, diarrhea, constipation, abdominal pain, mouth ulcer, indigestion, loss of appetite.
Central Nervous System - Weakness, fatigue, headache.
Metabolic - Decreased weight and fluid retention.
Blood - Anemia, decrease in white blood cells and platelets.
Miscellaneous - Fever, chills, cough, difficulty in breathing, fast heart rate.
* Avoid excess dosage. Storage Conditions :
Store it at room temperature.
Comment & Contribute
Ask an Expert