Trade Names/Brand Names :
Why it is prescribed :
This medication is a kinase inhibitor, prescribed for metastatic colorectal cancer (CRC) in patients who have been previously treated with fluoropyrimidine- oxaliplatin-and irinotecan-based chemotherapy. It works by helping to stop cancer cells from growing.
Category D :
There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.
Dosage & When it is to be taken (Indications):
PO- The recommended dose is 160mg, once daily for the first 21 days of each 28-day cycle.
How it should be taken :
It comes as a tablet to take by mouth with food.
Warnings and Precautions :
• Caution should be exercised in patients with history of bleeding problems, high blood pressure, heart, liver, or kidney diseases, any allergy, who are taking other medications, during pregnancy and breastfeeding.
Avoid drinking grapefruit juice while taking this medication.
Patient may develop with increased risk of Reversible Posterior Leukoencephalopathy Syndrome (RPLS). If it is so consult with your doctor immediately.
Side Effects :
• Most Common
Weakness, fatigue, decreased appetite and food intake, Hand-foot skin reaction (HFSR) (palmar-plantar erythrodysesthesia [PPE]), diarrhea, weight loss, and infection.
Anemia, weight loss.
High blood pressure, bleeding.
Difficulty in breathing.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store it at controlled room temperature (15 to 30°C).