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Raltegravir

Updated on : August - 2012
Latest prescription information about Raltegravir. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Raltegravir
Pronunciation : ral-TEG-ra-vir
Therapeutic Classification : Antivirals
ICD Code : Y41.5
Trade Name(s): 
International- Isentress.
Why it is prescribed (Indications) : 
This medication is an antiretroviral agent, prescribed for HIV/AIDS. It blocks HIV-1 integrase, an enzyme needed for the HIV virus growth.  
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult- Oral- The recommended dose is 400 mg, twice daily.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver problems or hepatitis B or C, muscle weakness, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid stopping of this medication due to short supply. Store sufficient quantity.
* Avoid sexual intercourse during the treatment; otherwise infection may spread.
*Patient may develop Immune Reconstitution Syndrome.
Side Effects : 
Most Common- Sleeplessness.
Gastrointestinal Disorders- Abdominal pain, stomach inflammation and nausea.
Liver- Liver inflammation.
Immune System- Hypersensitivity.
Central Nervous System- Dizziness, headache, weakness and fatigue.
Genitourinary- Kidney failure.
Other Precautions : 
* Monitor complete blood counts regularly while taking this medication.
Storage Conditions : 
Store it at room temperature (25°C), and in an airtight container. Keep away from children.
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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