Trade Names/Brand Names :
Why it is prescribed :
This medication is an alpha particle-emitting radioactive therapeutic agent indicated for treatment of patients with metastatic castration-resistant prostate cancer (mCRPC), symptomatic bone metastases and no known visceral metastatic disease.
When it is not to be taken (Contraindications):
Contraindicated in women who are pregnant.
Category X :
Animal and/or human studies have demonstrated fetal injury and potential risks outweigh the benefits of the drug in pregnancy. These drugs are found to be harmful when taken during pregnancy, and should not be used.
Dosage & When it is to be taken (Indications):
The recommended dosage is 50 kBq (1.35 microcurie) per kg body weight, given at 4 week intervals for 6 injections.
How it should be taken :
It comes as an intravenous single use injection vials.
Warnings and Precautions :
• Caution is needed in patients who have bone marrow problems. This medication can cause blood cell counts to go down and result in bone marrow suppression.
• Caution is needed in women who are planning to become pregnant, nursing mothers and pediatric. Safety and efficacy have not been established for these people.
Side Effects :
• Gastrointestinal Disorders
- Nausea, diarrhea, vomiting.
• Blood and Lymphatic System Disorders
- Reduction in the number of blood cells.
• Renal and Urinary Disorders
- Renal failure and impairment.
• Hematologic Laboratory Abnormalities
- Anemia, low lymphocyte count, decrease in leukocytes, reduced platelet count, low number of neutrophils.
- Swelling of arms or legs.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store at room temperature below 40° C (104° F) in the original container or equivalent radiation shielding.