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Quinupristin and Dalfopristin

Latest prescription information about Quinupristin and Dalfopristin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Quinupristin and Dalfopristin
Pronunciation : KWIN-ue-PRIS-tin-DAL-foe-PRIS-tin
Therapeutic Classification : Anti- Infectives
ICD Code : Y41.8
Trade Name(s): 
International- Synercid.
Why it is prescribed (Indications) : 
This medication is a streptogramin antibiotic, prescribed for certain bacterial infection (e.g. complicated skin and skin structure infections). It fights bacteria in the body.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
IV- The recommended dose is 7.5 mg/kg two times per day.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of liver or kidney impairment, stomach or bowel problems, HIV infection, high blood bilirubin levels, heart disease, who are taking other medications, any allergy, children, during pregnancy and breastfeeding.
* Avoid long-term use of this medication.
* Avoid becoming dehydrated.
Side Effects : 
Body as a Whole - Pain at injection site, abdominal pain, worsening of underlying illness, allergic reaction, chest pain, fever, infection.
Heart - Fluid retention, palpitation, vein inflammation.
Gastrointestinal - Nausea, vomiting, constipation, indigestion, mouth infection, inflammation of pancreas, mouth ulcer.
Metabolic - Gout, swelling in the extremities.
Musculoskeletal - Joint pain, muscle pain, muscle spasm.
Central Nervous System - Headache, anxiety, confusion, dizziness, increased muscle tone, sleeplessness, leg cramps, tingling, dilatation of blood vessels.
Respiratory - Difficulty in breathing, lung infection.
Skin - Rash, sweating, hives.
Genitourinary - Blood in urine, vaginal inflammation.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2 to 8°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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