Quinine - Drug Information

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General Information on Quinine

Generic Name : Quinine

Pronunciation : kwye' nine

Latest prescription information about Quinine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.2 | Therapeutic Classification : Anti- Malarials

Why is Quinine Prescribed? (Indications)

This medication is an antimalarial agent, prescribed for malaria and nighttime leg muscle cramps. It works by killing the malaria parasite.

When should Quinine not to be taken? (Contraindications)

Contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, myasthenia gravis and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Quinine?

Adult: PO- Malaria As sulfate: The recommended dose is 648 mg 8 hourly for 7 days.
Nocturnal leg cramps- The recommended dose is 200-300 mg at bedtime.

How should Quinine be taken?

It comes as a capsule and tablet to take by mouth, with food.

What are the warnings and precautions for Quinine?

Caution should be exercised in patients with history of prolonged QT interval, heart, kidney, or liver disease, abnormal electrocardiogram, G-6-PD deficiency, myasthenia gravis, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, lightheadedness, or blurred vision, do not drive a car or operate machinery while taking this medication.
Avoid exposure to sunlight.
It may affect platelet counts, avoid injury or bruising.

What are the side effects of Quinine?

   Most Common : Headache, dilatation of blood vessels, sweating, nausea, ringing in the ear, hearing impairment, dizziness, blurred vision and disturbances.
   General : Fever, chills, flushing, weakness, lupus-like syndrome and hypersensitivity reactions.
   Central Nervous System : Confusion, altered mental status, seizures, coma, disorientation, tremors, restlessness and incoordination.
   Skin : Rash, hives, itching and skin inflammation.
   Respiratory : Asthma, difficulty in breathing and lung swelling.
   Heart : Chest pain, dilatation of blood vessels, low blood pressure, fast heart rate, palpitations, QT prolongation and fainting.
   Gastrointestinal : Vomiting, diarrhea, abdominal pain, gastric irritation and heartburn.
   Liver : Jaundice and abnormal liver function tests.
   Metabolic : Decrease in sugar and loss of appetite.
   Musculoskeletal : Muscle pain and muscle weakness.
   Genitourinary : Kidney failure/ inflammation.
   Eye and ENT : Sudden loss of vision, sensitivity to light, double vision, night blindness, diminished visual fields, fixed pupillary dilatation, disturbed color vision, eye inflammation, blindness, unsteadiness, ringing in the ear, hearing impairment and deafness.

What are the other precautions for Quinine?

Avoid excess dosage.

What are the storage conditions of Quinine?

Store it at room temperature.

♦ Safety Labeling Changes Approved By FDA

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khushi297 

Hi, I had quinarsol 300mg for night cramps, it was ok when i had taken 12 tablets regulary once in a day, but 13th tablet i have taken after allegra180 with in 3 hours gape, its side effects are vomitting, diarreoh,stomach ache,shivering and high temprature. that's why we have taken 14th tablet without any aother dose, but still mine stomach get disturb, eyes become rep and swell with high temprature. now what should i do to eliminate its side effects and what is your advice for future. Regards, Khushi Sharma.

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