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Protamine Sulphate

Latest prescription information about Protamine Sulphate. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Protamine Sulphate
Pronunciation : PRO-tuh-meen SULL-fate
Therapeutic Classification : Heparin Antagonists
Trade Name(s): 
India- Prothiobin, Prota, Neutrahep, Neoprota, Newtain.
International- Protamine Sulfate.
Why it is prescribed (Indications) : 
This medication is a heparin antagonist, prescribed for reversing the anticoagulant effects of heparin. 
When it is not to be taken (Contraindications): 
Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV- 1 mg for each 90 units of heparin derived from lung tissue or 115 units of heparin derived from intestinal mucosa.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of poor blood circulation, heparin rebound, lung swelling, any allergy, children, during pregnancy and breastfeeding.
* Avoid too much rapid application.
* Monitor prothrombin time regularly while taking this medication.
Side Effects : 
Heart - Low blood pressure, slow heart rate, and circulatory collapse.
Central Nervous System - Lassitude.
Gastrointestinal - Nausea and vomiting.
Respiratory - Shortness of breath, lung swelling and acute pulmonary hypertension.
Miscellaneous - Severe respiratory distress, poor blood circulation, noncardiogenic lung swelling; transient flushing and feeling of warmth and back pain.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15 and 30°C). Do not freeze.


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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