Propoxyphene - Drug Information

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General Information on Propoxyphene

Generic Name : Propoxyphene

Pronunciation : proe pox' i feen

Latest prescription information about Propoxyphene. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.0 | Therapeutic Classification : Analgesics

Trade Names/Brand Names of Propoxyphene

India : 

International : 

Darvon, Darvon-N

Why is Propoxyphene Prescribed? (Indications)

This medication is an opioid analgesic, prescribed for mild to moderate pain.  

When should Propoxyphene not to be taken? (Contraindications)

Contraindicated in patients with significant respiratory depression, paralytic ileus and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Propoxyphene?

Adult: PO- As HCI: 65 mg 3-4 times/day. As napsilate: 100 mg 3-4 times/day.

How should Propoxyphene be taken?

It comes as a tablet and capsule to take by mouth, with or without food.

What are the warnings and precautions for Propoxyphene?

• Caution should be exercised in patients with history of liver or kidney disease, alcoholism, any allergy, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
• Avoid alcoholic beverages.
• It should not be used in children less than 12 years.

What are the side effects of Propoxyphene?

•   Most Common : Dizziness, sedation, nausea, vomiting, constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness, emotional state, hallucinations and minor visual disturbances.
•   Heart : Abnormal heart rhythm, slow/fast heart rate, heart/respiratory arrest, heart failure, heart attack and low blood pressure.
•   Eye : Eye swelling and blurred vision.
•   General : Drug interaction, drug tolerance and drug withdrawal syndrome.
•   Gastrointestinal : Gastrointestinal bleeding and inflammation of pancreas.
•   Liver : Liver enlargement.
•   Immune system : Hypersensitivity.
•   Metabolic : Acidity.
•   Central Nervous system : Incoordination, coma, dizziness, drowsiness and fainting.
•   Psychiatric : Abnormal behavior, confusional state and status change.
•   Respiratory : Respiratory depression and difficulty in breathing.
•   Skin : Rash and itching.

What are the other precautions for Propoxyphene?

Avoid excess dosage.

What are the storage conditions of Propoxyphene?

Store it at controlled room temperature (5-30°C).

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