Prochlorperazine - Drug Information

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General Information on Prochlorperazine

Generic Name : Prochlorperazine

Pronunciation : proe klor per' a zeen

Latest prescription information about Prochlorperazine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics

Why is Prochlorperazine Prescribed? (Indications)

This medication is a tranquilizer, prescribed for schizophrenia, severe nausea and vomiting.  

When should Prochlorperazine not to be taken? (Contraindications)

Contraindicated in patients with CNS depression, children less than 2 years old, and hypersensitivity.

Pregnancy Category

A B C D X

Category N :

Not yet classified.

What is the dosage of Prochlorperazine?

Nausea and Vomiting - Oral Dosage: Tablets: Take one 5 mg or 10 mg tablet 3 or 4 times daily.
Rectal Dosage: 25 mg twice daily.
I.M. Dosage: Initially 5 to 10 mg (1 to 2 mL) injected deeply.
Adult Psychiatric Disorders- Oral Dosage: The recommended dosage is 5 mg 3 or 4 times daily.

How should Prochlorperazine be taken?

It comes as a tablet, capsule, liquid to take by mouth, with or without food.
It also comes as a solution for injection to be administered by a healthcare provider into the vein or muscle.
It also comes as rectal suppositories, to insert through the rectum.

What are the warnings and precautions for Prochlorperazine?

• Caution should be exercised in patients with history of heart disease, central nervous system depression, liver problems, low blood pressure, increased eye pressure, neuroleptic malignant syndrome, tardive dyskinesia, bone marrow depression, involuntary muscle movements, Parkinson disease, Reye syndrome, prostate enlargement, seizures, alcoholism, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
• It may cause drowsiness, dizziness, blurred vision or lightheadedness, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Avoid exposure sunlight.

What are the side effects of Prochlorperazine?

   Most Common : Drowsiness, dizziness, absence of menstrual periods, blurred vision, skin reactions and Neuroleptic Malignant Syndrome (NMS).
   Gastrointestinal : Nausea, constipation and bowel obstruction.
   Genitourinary : Ejaculatory disorders/impotence, painful erection, lazy colon, urinary retention, menstrual irregularities and false-positive pregnancy tests.
   Heart : Low blood pressure and heart arrest.
   Blood : Blood dyscrasias.
   Liver : Jaundice and liver damage.
   Metabolic : Increased appetite and increased weight.

What are the other precautions for Prochlorperazine?

Avoid excess dosage.

What are the storage conditions of Prochlorperazine?

Store it at controlled room temperature (15° and 30°C).

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