Procarbazine - Drug Information

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General Information on Procarbazine

Generic Name : Procarbazine

Pronunciation : proe kar' ba zeen

Latest prescription information about Procarbazine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Procarbazine

India : 

International : 

Matulane

Why is Procarbazine Prescribed? (Indications)

This medication is an antineoplastic agent, prescribed for Hodgkin disease.  It inhibits protein, RNA, and DNA synthesis that help to stop the cancer cell growth.

When should Procarbazine not to be taken? (Contraindications)

Contraindicated in patients with bone marrow depression and hypersensitivity.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Procarbazine?

Adult: The recommended dose is 24 mg/kg/day either in a single dose or divided, given for 7 days then increased to 46 mg/kg/day.

How should Procarbazine be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Procarbazine?

Caution should be exercised in patients with history of congestive heart failure, adrenal gland tumors (eg, pheochromocytoma), bone marrow depression, heart disease, frequent headaches, mental problems, kidney, or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
Avoid exposure to sunlight.
It may reduce platelet counts, avoid bruising or injury.

What are the side effects of Procarbazine?

   Blood : Nose bleed, bruising, anemia and eosinophilia.
   Gastrointestinal : Liver dysfunction, jaundice, mouth ulcer, blood vomiting, blood in stool, diarrhea, indigestion, loss of appetite, abdominal pain, constipation and dry mouth.
   Central Nervous System : Coma, convulsions, nerve disease, incoordination, tingling, night blindness, diminished reflexes, falling, foot drop, headache, dizziness and unsteadiness.
   Heart : Low blood pressure, fast heart rate and fainting.
   Eye : Eye bleeding, sensitivity to light, double vision, optic disc swelling and inability to focus.
   Respiratory : Lung inflammation/infection and increased cough.
   Skin : Skin inflammation, itching, hair loss, pigmentation, rash, hives and flushing.
   Allergic reactions : Generalized allergic reactions.
   Genitourinary : Blood in urine, urinary frequency, nighttime urination and breast enlargement in male.
   Musculoskeletal : Pain, including muscle and joint pain and tremors.
   Psychiatric : Hallucinations, depression, apprehension, nervousness, confusion and nightmares.
   Miscellaneous : Infections, hearing loss, fever, increased sweating, lethargy, weakness, fatigue, edema, chills, sleeplessness, slurred speech, hoarseness and drowsiness.

What are the other precautions for Procarbazine?

Avoid excess dosage.

What are the storage conditions of Procarbazine?

Store it at room temperature.


Schedule : G

Drugs that are to be used only under medical supervision.

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