Probenecid - Drug Information

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General Information on Probenecid

Generic Name : Probenecid

Pronunciation : proe ben' e sid

Latest prescription information about Probenecid. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Gout Therapy

Trade Names/Brand Names of Probenecid

India : 

International : 

Benemid

Why is Probenecid Prescribed? (Indications)

This medication is a uricosuric agent, prescribed for chronic gout and gouty arthritis. It increases the excretion of uric acid from the body.

When should Probenecid not to be taken? (Contraindications)

Contraindicated in children under 2 years of age, persons with known blood dyscrasias, kidney stone, hypersensitivity, during pregnancy and breastfeeding.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Probenecid?

PO- The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily.

How should Probenecid be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Probenecid?

Caution should be exercised in patients with history of ulcers, kidney stones,kidney disorder, blood disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
It may affect blood sugar level, monitor sugar level regularly.

What are the side effects of Probenecid?

   Central Nervous System : Headache and dizziness.
   Metabolic : Precipitation of acute gouty arthritis.
   Gastrointestinal : Liver damage, vomiting, nausea, loss of appetite and sore gums.
   Genitourinary : Kidney damage, blood in urine, kidney stone, back pain and urinary frequency.
   Hypersensitivity : Shock, fever, hives and itching.
   Blood : Anemia and decrease in white blood cells.
   Skin : Skin inflammation, hair loss and flushing.

What are the other precautions for Probenecid?

Drink adequate fluid especially during the first few months of treatment.

What are the storage conditions of Probenecid?

Store it at room temperature (20-25C).

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