Piperacillin/Tazobactam - Drug InformationGeneric Name : Piperacillin/Tazobactam | Pronunciation : PI-per-a-SIL-in/TAZ-oh-BAK-tam
Why it is prescribed (Indications) :
This combination medication is an antibacterial agent, prescribed for various infections such as Nosocomial pneumonia. It blocks the bacteria's cell wall growth, which kills the bacteria. Tazobactam inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
When it is not to be taken (Contraindications):
Pregnancy Category :
Category B :Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Dosage & When it is to be taken :
IV- The recommended dose is 3.375 mg 4 times a day, for 7 to 10 days. A higher initial dose of 4.5 mg 4 times a day may be used for more severe infections.
How it should be taken :
It comes as a solution for injection, administered by a healthcare provider.
Warnings and Precautions :Caution should be exercised in patients with history of asthma; hay fever; or kidney, liver, or gastrointestinal disease (especially colitis), during pregnancy and breastfeeding.
Repeated electrolyte estimations may be needed especially in patients with low potassium levels.
Monitor blood functions regularly.
Side Effects :
It may lead to increase risk of fever, rashes in patients with cystic fibrosis, bleeding, super infections, convulsions, kidney failure.
Allergic Reactions- Diarrhea, severe allergic reactions, skin rashes, itching, occasionally platelet mediated bleeding, rigors, malaise, inflammation in stomach.
Local- Injection-site reactions such as pain, swelling, redness, indurations and vein inflammation.
Gastrointestinal- Inflammation of stomach, hairy tongue, inflammation of colon, nausea and vomiting, blood in stool.
Genitourinary- Urine retention, painful urination.
Blood- Decrease in white blood cells.
Lab- Increase in liver enzymes, blood urea nitrogen, and presence of red blood cells in urine.
Miscellaneous- Chills, facial swelling, mucosal bleeding, tightness in throat.