Information about Physostigmine

Generic Name : Physostigmine
Up-to-date prescription details regarding Physostigmine are provided here.

Pronunciation : fye-soe-STIG-meen

Learn the correct pronunciation of the Physostigmine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y51.0 Therapeutic Classification : Anticholinergic antidotes

Trade Names/Brand Names of Physostigmine

India :

Bi Miotic | Bi-Miltic

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International :

Antilirium, Eserine Salicylate, Isopto Eserine, and Eserine Sulfate

Why is Physostigmine Prescribed? (Indications)

This medication is a reversible cholinesterase inhibitor alkaloid, prescribed for reversal of anticholinergic toxicity. It increases the amount of fluid that drains from the eye.

When should Physostigmine not be taken? (Contraindications)

It should not be used in patients with asthma, gangrene, diabetes, heart disease, obstruction of the intestine or urogenital tract, in patients receiving choline esters and depolarizing neuromuscular blocking agents.

What is the dosage of Physostigmine?

Dosage: Adults- IV- 0.5 to 1 mg infused over at least 5 min; repeat in 10 to 15 min as clinically indicated.
Children- IV- 0.02 mg/kg (up to 0.5 mg) infused over at least 5 min; repeat in 10 to 15 min as clinically indicated (up to a total dose of 2 mg).
Post anesthesia care- Adults- IV/IM- 0.5 to 1 mg; repeat at intervals of 10 to 30 min as clinically indicated.

How should Physostigmine be taken?

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Physostigmine?

• Caution should be exercised in patients with history of QT prolongation, during pregnancy and breastfeeding.

• Patient may develop with severe allergic reactions; Keep atropine in hand to treat.