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Physostigmine
Latest prescription information about Physostigmine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Physostigmine
Pronunciation : fye-soe-STIG-meen
Therapeutic Classification : Anticholinergic antidotes
ICD Code : Y51.0
Trade Name(s): India- Bi-Miltic - Pilocarpine+Physostigmine. International- Antilirium, Eserine Salicylate, Isopto Eserine, and Eserine Sulfate. Why it is prescribed (Indications) : This medication is a reversible cholinesterase inhibitor alkaloid, prescribed for reversal of anticholinergic toxicity. It increases the amount of fluid that drains from the eye. When it is not to be taken (Contraindications): It should not be used in patients with asthma, gangrene, diabetes, heart disease, obstruction of the intestine or urogenital tract, in patients receiving choline esters and depolarizing neuromuscular blocking agents.
Dosage & When it is to be taken : Dosage: Adults- IV- 0.5 to 1 mg infused over at least 5 min; repeat in 10 to 15 min as clinically indicated. Children- IV- 0.02 mg/kg (up to 0.5 mg) infused over at least 5 min; repeat in 10 to 15 min as clinically indicated (up to a total dose of 2 mg). Post anesthesia care- Adults- IV/IM- 0.5 to 1 mg; repeat at intervals of 10 to 30 min as clinically indicated. How it should be taken : It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions : * Caution should be exercised in patients with history of QT prolongation, during pregnancy and breastfeeding. * Patient may develop with severe allergic reactions; Keep atropine in hand to treat. Side Effects : Heart- Low heart beat. Central Nervous System- Epilepsy. Gastrointestinal- Nausea, vomiting and salivation. * Avoid rapid administration; otherwise it will cause slow heart rate/respiratory problem. Storage Conditions : Store it at controlled room temperature (20° to 25°C) and in an airtight container. |
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