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Generic Name : Physostigmine
Pronunciation : fye-soe-STIG-meen
Therapeutic Classification : Anticholinergic antidotes
ICD Code : Y51.0
Trade Name(s): India- Bi-Miltic - Pilocarpine+Physostigmine. International- Antilirium, Eserine Salicylate, Isopto Eserine, and Eserine Sulfate. Why it is prescribed (Indications) : This medication is a reversible cholinesterase inhibitor alkaloid, prescribed for reversal of anticholinergic toxicity. It increases the amount of fluid that drains from the eye. When it is not to be taken (Contraindications): It should not be used in patients with asthma, gangrene, diabetes, heart disease, obstruction of the intestine or urogenital tract, in patients receiving choline esters and depolarizing neuromuscular blocking agents.
Dosage & When it is to be taken : Dosage: Adults- IV- 0.5 to 1 mg infused over at least 5 min; repeat in 10 to 15 min as clinically indicated. Children- IV- 0.02 mg/kg (up to 0.5 mg) infused over at least 5 min; repeat in 10 to 15 min as clinically indicated (up to a total dose of 2 mg). Post anesthesia care- Adults- IV/IM- 0.5 to 1 mg; repeat at intervals of 10 to 30 min as clinically indicated. How it should be taken : It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions : * Caution should be exercised in patients with history of QT prolongation, during pregnancy and breastfeeding. * Patient may develop with severe allergic reactions; Keep atropine in hand to treat. Side Effects : Heart- Low heart beat. Central Nervous System- Epilepsy. Gastrointestinal- Nausea, vomiting and salivation. * Avoid rapid administration; otherwise it will cause slow heart rate/respiratory problem. Storage Conditions : Store it at controlled room temperature (20° to 25°C) and in an airtight container. |
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