Generic Name : Physostigmine Pronunciation : fye-soe-STIG-meen Therapeutic Classification : Anticholinergic antidotes ICD Code : Y51.0
India- Bi-Miltic - Pilocarpine+Physostigmine.
International- Antilirium, Eserine Salicylate, Isopto Eserine, and Eserine Sulfate. Why it is prescribed (Indications) :
This medication is a reversible cholinesterase inhibitor alkaloid, prescribed for reversal of anticholinergic toxicity. It increases the amount of fluid that drains from the eye. When it is not to be taken (Contraindications): It should not be used in patients with asthma, gangrene, diabetes, heart disease, obstruction of the intestine or urogenital tract, in patients receiving choline esters and depolarizing neuromuscular blocking agents.
Dosage & When it is to be taken :
Dosage: Adults- IV- 0.5 to 1 mg infused over at least 5 min; repeat in 10 to 15 min as clinically indicated.
Children- IV- 0.02 mg/kg (up to 0.5 mg) infused over at least 5 min; repeat in 10 to 15 min as clinically indicated (up to a total dose of 2 mg).
Post anesthesia care- Adults- IV/IM- 0.5 to 1 mg; repeat at intervals of 10 to 30 min as clinically indicated. How it should be taken :
It comes as a solution for injection, to be administered by a healthcare provider into the vein. Warnings and Precautions :
* Caution should be exercised in patients with history of QT prolongation, during pregnancy and breastfeeding.
* Patient may develop with severe allergic reactions; Keep atropine in hand to treat.
Side Effects :
Heart- Low heart beat.
Central Nervous System- Epilepsy.
Gastrointestinal- Nausea, vomiting and salivation.
* Avoid rapid administration; otherwise it will cause slow heart rate/respiratory problem.
Storage Conditions :
Store it at controlled room temperature (20° to 25°C) and in an airtight container.
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