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Perphenazine

Latest prescription information about Perphenazine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Perphenazine
Pronunciation : per fen' a zeen
Therapeutic Classification : psychotherapeutics
Trade Name(s): 
International- Trilafon.
Why it is prescribed (Indications) : 
This medication is a tranquilizer, prescribed for schizophrenia (a mental illness).

When it is not to be taken (Contraindications): 


Contraindicated in patients with blood disorders, liver damage, decreased bone marrow function, brain damage, who are taking astemizole, cisapride, terfenadine, or tramadol, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Nonhospitalized patients - Initial- 4 to 8 mg three times per day; it may be reduced.
Hospitalized patients - 8 to 16 mg 2 to 4 times/day; Maximum- 64 mg daily.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Special Instruction : 
* Caution should be exercised in patients with history of seizures, breast cancer, asthma, trouble in urinating, lung disease, alcohol abuse, depression, heart disease, Reye syndrome, Parkinson disease, increased eye pressure, high/low blood pressure, prostate enlargement, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause drowsiness, dizziness, or fainting, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
* Avoid alcohol consumption.
* Avoid exposure to sunlight.
* Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. If it is so consult with your doctor.
* Do not become overheated in hot weather; otherwise heatstroke may occur.
Side Effects : 
Central Nervous System - Tardive dyskinesia with symptoms like involuntary movements; neuroleptic malignant syndrome with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating; drowsiness, tiredness, excitement, restlessness, hyperactivity, confusion, abnormal dreams and sleeplessness.
Gastrointestinal - Dry mouth or salivation, nausea, vomiting, diarrhea, loss of appetite, constipation and fecal impaction.
Genitourinary - Urinary retention, frequency or incontinence, bladder paralysis, spontaneous secretion of milk, moderate breast enlargement in females and breast enlargement in males on large doses and irregular periods.
Eye and ENT - Constriction/dilatation of pupil, blurred vision and increased eye pressure.
Heart - Low/high blood pressure and changes in pulse rate.
Allergic Reactions - Hives, redness, skin inflammation, itching, sensitivity to light, asthma, shock and fever.
Other Precautions : 
* Monitor liver, kidney functions and complete blood cell counts regularly while taking this medication.
* It should not be used in children less than 12 years old.
Storage Conditions : 
Store it at room temperature (20°-25°C).

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