Perphenazine - Drug Information

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General Information on Perphenazine

Generic Name : Perphenazine

Pronunciation : per fen' a zeen

Latest prescription information about Perphenazine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.3 | Therapeutic Classification : Psychotherapeutics

Trade Names/Brand Names of Perphenazine

International- Trilafon.

Why is Perphenazine Prescribed? (Indications)

This medication is a tranquilizer, prescribed for schizophrenia (a mental illness). It decreases abnormal excitement in the brain.

When should Perphenazine not to be taken? (Contraindications)

Contraindicated in patients with blood disorders, liver damage, decreased bone marrow function, brain damage, who are taking astemizole, cisapride, terfenadine, or tramadol, and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Perphenazine?

Nonhospitalized patients - Initial- 4 to 8 mg three times per day; it may be reduced.
Hospitalized patients - 8 to 16 mg 2 to 4 times/day; Maximum- 64 mg daily.

How should Perphenazine be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Perphenazine?

Caution should be exercised in patients with history of seizures, breast cancer, asthma, trouble in urinating, lung disease, alcohol abuse, depression, heart disease, Reye syndrome, Parkinson disease, increased eye pressure, high/low blood pressure, prostate enlargement, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness, dizziness, or fainting, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
Avoid alcohol consumption.
Avoid exposure to sunlight.
Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating. If it is so consult with your doctor.
Do not become overheated in hot weather; otherwise heatstroke may occur.

What are the side effects of Perphenazine?

   Central Nervous System : Tardive dyskinesia with symptoms like involuntary movements; neuroleptic malignant syndrome with the following symptoms: fever, stiff muscles, confusion, abnormal thinking, fast or irregular heartbeat, and sweating; drowsiness, tiredness, excitement, restlessness, hyperactivity, confusion, abnormal dreams and sleeplessness.
   Gastrointestinal : Dry mouth or salivation, nausea, vomiting, diarrhea, loss of appetite, constipation and fecal impaction.
   Genitourinary : Urinary retention, frequency or incontinence, bladder paralysis, spontaneous secretion of milk, moderate breast enlargement in females and breast enlargement in males on large doses and irregular periods.
   Eye and ENT : Constriction/dilatation of pupil, blurred vision and increased eye pressure.
   Heart : Low/high blood pressure and changes in pulse rate.
   Allergic Reactions : Hives, redness, skin inflammation, itching, sensitivity to light, asthma, shock and fever.

What are the other precautions for Perphenazine?

Monitor liver, kidney functions and complete blood cell counts regularly while taking this medication.
It should not be used in children less than 12 years old.

What are the storage conditions of Perphenazine?

Store it at room temperature (20-25C).

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