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Pentazocine and Naloxone

Latest prescription information about Pentazocine and Naloxone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Pentazocine and Naloxone
Pronunciation : pen taz' oh seen- nal ox' one
Therapeutic Classification : Analgesics
ICD Code : Y45.8
Trade Name(s): 
International- Talwin NX.
Why it is prescribed (Indications) : 
This combination medication is an analgesic, prescribed for moderate to severe pain. It inhibits the action of the substances that cause pain.  
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adults- The usual initial adult dose is 1 tablet every three or four hours. This may be increased to 2 tablets when needed. Total daily dosage should not exceed 12 tablets.
How it should be taken : 
It comes as a tablet to take by mouth, with food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of electrolyte imbalance, breathing problems, high blood pressure, heart disease, under active thyroid, Addison disease, liver or kidney disease, enlarged prostate, trouble in urinating, porphyria, stomach problems, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
Side Effects : 
Central Nervous System - Drowsiness, dizziness, lightheadedness, nervousness, apprehension, depression, floating feeling, headache, weakness, faintness, disturbed dreams and sleeplessness.
Gastrointestinal - Nausea, vomiting and constipation.
Heart - High or low blood pressure, fast heart rate and poor blood circulation.
Metabolic - Increased sweating, flushing of the skin, dry mouth and altered taste.
Allergic reactions - Swelling of the face, shock, skin inflammation, itching, flushed skin, rash and hives.
Eye - Blurred vision and difficulty in focusing.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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