Generic Name : Pentamidine Pronunciation : pen tam' i deen Therapeutic Classification : Miscellaneous Anti- Infectives ICD Code : Y41
International- Pentam, Nebupent. Why it is prescribed (Indications) :
This medication is an antimicrobial agent, prescribed for pneumonia and for treating leishmaniasis, yeast infections. This medication proved to be an effective antibiotic in children undergoing leukemia treatment. When it is not to be taken (Contraindications):
Dosage & When it is to be taken :
IV/IM- The recommended dose is 4 mg/kg/day or on alternate days. Total: 7-10 doses. How it should be taken :
It comes as a solution for injection, to be administered by a healthcare provider. Warnings and Precautions :
* Caution should be exercised in patients with history of asthma, smoking, decreased level of potassium, magnesium in blood, heart diseases, prolonged QT interval, diabetes, high/low blood pressure, high/low blood sugar, anemia, liver or kidney impairment during pregnancy and breastfeeding.
* Monitor: Blood pressure, liver and kidney function, blood-glucose and serum-calcium concentrations and blood counts. Side Effects :
Most Common- Vomiting, infection and loss of appetite.
Body as a Whole - Night sweats, allergic reaction, body odor, swelling in the face/leg, fever, lethargy and chills.
Heart- Stroke, high/low blood pressure, palpitations, poor blood circulation, fainting, fast heart rate and dilatation of blood vessels.
Gastrointestinal- Diarrhea, nausea, abdominal cramps, abdominal pain, constipation, dry mouth, indigestion, inflammation of stomach/gum, gastric ulcer, hernia, increased saliva, oral ulcer/abscess and enlargement of the spleen.
Blood- Anemia, eosinophilia and decreased volume of blood cells.
Liver - Liver enlargement and liver dysfunction/inflammation.
Metabolic- Increased/decreased sugar level and decreased calcium concentration.
Musculoskeletal- Joint/muscle pain and gout.
Central Nervous System- Headache, anxiety, confusion, depression, drowsiness, frequent mood changes, hallucination, sensory loss, sleeplessness, memory loss, nerve pain, personality disorder, tingling, peripheral nerve damage, seizure, tremors and vertigo.
Genitourinary- Kidney damage and miscarriage.
Respiratory - Chest pain, cough, asthma, shortness of breath and wheezing.
Skin- Desquamation, dry and breaking hair, dry skin, redness, itching, rash and hives.
Eye and ENT- Bad taste, inflammation of eyelid, conjunctiva, blurred vision, contact lens discomfort, eye pain or discomfort, nonspecific odor and smell.
*Avoid excess dosage. Storage Conditions :
Injection: Before reconstitution: protect from light and keep at room temperature (do not refrigerate as crystals may form); once reconstituted: store at 2-8 °C and use within 24 hours.
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