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Papaverine

Latest prescription information about Papaverine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Papaverine
Pronunciation : pa pav' er een
Therapeutic Classification : Vasodilators
ICD Code : Y51.3
Trade Name(s): 
India- Paparin vial.
International- Para-Time SR.
Why it is prescribed (Indications) : 
This medication is a vasodilating agent, prescribed for the relief from smooth muscle spasm, cerebral and peripheral ischemia (inadequate blood supply) associated with arterial spasm. It works by relaxing the blood vessels.
When it is not to be taken (Contraindications): It should not be given in large doses and contraindicated in patients with hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Capsule- Adults: 150 mg 2 times per day. The dose may be increased to 150 mg 3 times or 300 mg 2 times per day.
Tablet- Adults: 100 to 300 mg in divided doses.
IV/IM- 1 to 4 mL is repeated every 3 hours.
How it should be taken : 
It comes as a tablet and capsule to take by mouth, with or without food. It also comes as a solution for injection to be administered by a healthcare provider into the vein or muscle.
Warnings and Precautions : 
* Caution should be exercised in patients with history of increased eye pressure, liver or heart problems, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
Side Effects : 
Gastrointestinal - Nausea, abdominal distress, loss of appetite, constipation and diarrhea.
Central Nervous System - Uneasiness, drowsiness, unsteadiness, sweating and headache.
Miscellaneous - Skin rash, flushing of face, increase in heart rate and depth of respiration, slight increase in blood pressure and excessive sedation.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (20° to 25°C) and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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