Papaverine - Drug Information

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General Information on Papaverine

Generic Name : Papaverine

Pronunciation : pa pav' er een

Latest prescription information about Papaverine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y51.3 | Therapeutic Classification : Vasodilators

Trade Names/Brand Names of Papaverine

India : 

International : 

Para-Time SR

Why is Papaverine Prescribed? (Indications)

This medication is a vasodilating agent, prescribed for the relief from smooth muscle spasm, cerebral and peripheral ischemia (inadequate blood supply) associated with arterial spasm. It works by relaxing the blood vessels.

When should Papaverine not to be taken? (Contraindications)

It should not be given in large doses and contraindicated in patients with hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Papaverine?

Capsule- Adults: 150 mg 2 times per day. The dose may be increased to 150 mg 3 times or 300 mg 2 times per day.
Tablet- Adults: 100 to 300 mg in divided doses.
IV/IM- 1 to 4 mL is repeated every 3 hours.

How should Papaverine be taken?

It comes as a tablet and capsule to take by mouth, with or without food. It also comes as a solution for injection to be administered by a healthcare provider into the vein or muscle.

What are the warnings and precautions for Papaverine?

Caution should be exercised in patients with history of increased eye pressure, liver or heart problems, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.

What are the side effects of Papaverine?

   Gastrointestinal : Nausea, abdominal distress, loss of appetite, constipation and diarrhea.
   Central Nervous System : Uneasiness, drowsiness, unsteadiness, sweating and headache.
   Miscellaneous : Skin rash, flushing of face, increase in heart rate and depth of respiration, slight increase in blood pressure and excessive sedation.

What are the other precautions for Papaverine?

Avoid excess dosage.

What are the storage conditions of Papaverine?

Store it at room temperature (20 to 25C) and in an airtight container. Keep away from children.

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