Norethindrone - Drug InformationGeneric Name : Norethindrone | Pronunciation : nor-ETH-in-drone
International :Ortho Micronor , Aygestin , Nor-QD
Why it is prescribed (Indications) :
This medication is synthetic oral progestin, used for the treatment of secondary amenorrhea (absence of periods for a few months but patient is not pregnant), endometriosis (the tissue that lines the inner wall of the uterus is found at other sites), and abnormal uterine bleeding due to hormonal imbalance. It induces secretory changes in the endometrium. It works by altering the lining of the uterus.
When it is not to be taken (Contraindications):Contraindicated in patients with severe liver dysfunction, undiagnosed vaginal bleeding, porphyria, pregnancy, previous or current blood clot, deep vein thrombosis, and hypersensitivity.
Pregnancy Category :
Category X :Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Dosage & When it is to be taken :
Adult: Oral- The recommended usual dose is 2.5 to 10 mg/day, for 5 to 10 day during the second half of the menstrual period. Endometriosis- 5mg/day for 14days, Max: 15mg/day for 6 to 9 months.
How it should be taken :
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions :Caution needed for patients with history of high blood pressure, heart disease, liver impairment, epilepsy, breastfeeding, new onset of migraine-type headache, asthma, kidney impairment, history of clinical depression.
Side Effects :
Most Common- Headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss.
Genitourinary- Change in sexual interest, changes in menstrual flow, changes in cervical mucus secretion.
Central Nervous System- Headache, dizziness, mood swings, trouble sleeping.
Heart- High blood pressure
Liver- Abnormal liver tests, jaundice.
Eye- Blurred/double vision, loss of vision.
Skin- Hives, rash, acne, growth of hair on face, increased pigmentation.
Metabolic- Increase in blood sugar, increased lipids.
Blood- Increase in blood clots in veins.