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Nitroxazepine

Latest prescription information about Nitroxazepine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Nitroxazepine
Therapeutic Classification : Psychotherapeutics
ICD Code : Y49.0
Trade Name(s): 
India- Sintamil.
Why it is prescribed (Indications) : 
This medication is a tricyclic antidepressant (TCA), prescribed for depression, and nocturnal enuresis. 
When it is not to be taken (Contraindications): 
Hypersensitivity.

Dosage & When it is to be taken : 
Adult- PO- The recommended dose is 25-50 mg at bedtime.
How it should be taken : 
It comes as a tablet to take by mouth, at bedtime.
Warnings and Precautions : 
* Caution should be exercised in patients with history of mental illness, any allergy, kidney or liver problems, diabetes, suicidal thoughts, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause drowsiness, dizziness, or blurred vision, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
* Avoid exposure sunlight.
Side Effects : 
Heart - Low blood pressure, high blood pressure, fast heart rate, palpitations, heart attack, abnormal heart rhythm, heart block, ECG changes, and stroke.
Central Nervous System - Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; sleeplessness and abnormal dreams, numbness, tingling, incoordination, ataxia, tremors, seizures, alterations in EEG patterns, and ringing in the ear.
Eye and ENT - Dry mouth, and, blurred vision, disturbances of accommodation and dilatation of pupil.
Allergic - Skin rash, petechiae, hives, itching, sensitivity to light, swelling in the eyes, face and tongue and drug fever.
Blood - Bone marrow depression including agranulocytosis and eosinophilia.
Gastrointestinal - Nausea and vomiting, loss of appetite, stomach distress, diarrhea, peculiar taste, mouth ulcer, abdominal cramps, black tongue, constipation, paralytic ileus.
Genitourinary - Breast enlargement in the male, spontaneous milk secretion in the female, increased or decreased sexual drive, impotence, testicular swelling, elevation or blood sugar level, urinary retention, delayed micturition and dilation of the urinary tract.
Miscellaneous - Jaundice, abnormal liver function, weight gain or loss, perspiration, flushing, urinary frequency, drowsiness, dizziness, weakness and fatigue, headache, parotid swelling, hair loss and proneness to falling.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store the medication as directed by your physician.


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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