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Nimotuzumab - Indications, Dosage, Side Effects and Precautions

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Information about Nimotuzumab

Generic Name : Nimotuzumab
Up-to-date prescription details regarding Nimotuzumab are provided here.

Pronunciation : Ni-motu-zu-mab

Learn the correct pronunciation of the Nimotuzumab, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Nimotuzumab

India :

Overview of Nimotuzumab

• Nimotuzumab is used for the treatment of glioma (cancer in brain and spinal cord).

Why is Nimotuzumab Prescribed? (Indications)

Nimotuzumab is a monoclonal antibody and an endothelial growth factor receptor (EGRF) antagonist.
It also stimulates the immune system against the cancer cells.

It is a targeted therapy used for the treatment of glioma (cancer in the brain and spinal cord), cancer of the head and neck, and nasopharyngeal cancer.
It prevents the growth and spread of the cancer.

The drug is approved for different cancers in different countries.
It has received orphan drug status for the treatment of glioma in the United States and pancreatic cancer in the European Union.

When should Nimotuzumab not be taken? (Contraindications)

• The drug is contraindicated if the patient is allergic to drug, or during pregnancy and breastfeeding in women.

What is the dosage of Nimotuzumab?

• The recommended dose of the drug in adults is 200 mg as a continuous intravenous infusion weekly with combination of radiation therapy for 6 weeks followed by 200 mg every 15 days as maintenance treatment.

How should Nimotuzumab be taken?

• Nimotuzumab should be administered diluted in 0.9% sodium chloride over 60 minutes in adults.

What are the warnings and precautions for Nimotuzumab?

• The drug should be administered with caution in the patients with diabetes, heart disease or hypertension.

• The antihistamine diphenhydramine should be administered before the infusion to prevent a reaction.

• Use with caution in patients who were previously treated with the murine monoclonal antibody.

What are the side effects of Nimotuzumab?

Gastrointestinal: Nausea, vomiting
Skin: Skin rash
Cardiovascular: Changes in blood pressure
Central nervous system: Drowsiness, disorientation
Others: Fever, chills, rigors, weakness, allergic reaction, blood in the urine, increase in liver enzymes

What are the other precautions for Nimotuzumab?

• Do not shake the vial.
• Inspect the vial for particulate matter and discoloration before use. Discard if present.

What are the Drug Interactions of Nimotuzumab?

• Not known.

What are the storage conditions for Nimotuzumab?

• Nimotuzumab should be stored under refrigeration at 2-8°C. Do not freeze.
• The diluted solution can be kept at room temperature between 22-27°C for up to 72 hours.
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