Generic Name : Niacin Er and Simvastatin Pronunciation : NYE a sin and SIM va stat in
International- Simcor. Why it is prescribed (Indications) :
This combination medication contains HMG-CoA reductase inhibitor and niacin, prescribed for hypercholesterolemia. When it is not to be taken (Contraindications): Contraindicated in patients with severe liver problem, peptic ulcer, arterial bleeding, during pregnancy and breastfeeding.
It should not be co-administered with CYP3A4 inhibitors, gemfibrozil, cyclosporine, or danazol, verapamil or diltiazem.
Dosage & When it is to be taken :
The recommended dose is 500/20 mg single tablet daily at bedtime.
The recommended maintenance dose is 1000/20 mg to 2000/40 mg (two 1000/20 mg tablets) once daily. How it should be taken :
It comes as a tablet to take by mouth, at bedtime. Warnings and Precautions :
* Caution should be exercised in patients with history of kidney or liver disease, jaundice, diabetes, underactive thyroid, metabolic problems, bleeding disorder, low blood pressure, gout, muscle pain or weakness, seizures, ulcers, dehydration, infection, alcoholism, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* It may cause liver damage; avoid alcohol consumption during the treatment period.
* It may reduce platelet counts; avoid injury or bruising. Side Effects :
Most Common - Dizziness, fainting, fast heart rate, palpitations, shortness of breath, sweating, burning sensation, chills, fluid retention.
Gastrointestinal - Abdominal pain, constipation, nausea , diarrhea, indigestion, and flatulence.
* Avoid excess dosage. Storage Conditions :
Store it at controlled room temperature (20°-25°C).
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