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Naloxone

Latest prescription information about Naloxone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Naloxone
Pronunciation : nal-OX-one
Trade Name(s): 
India- Nalox Inj, Narcotan Inj, Nex Amp.
International-Narcan.
Why it is prescribed (Indications) : 
This medication is an Opioid antagonist, prescribed for morphine and most other opioid poisoning. It is used to reverse respiratory depression in the newborn when the mother was administered opioids during labor. It is also indicated for the diagnosis of suspected acute opioid over dosage. It may also be useful in other conditions such as to increase blood pressure in certain types of shock, and central nervous system injuries.

When it is not to be taken (Contraindications): 


Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Adult: Opioid over dosage- The recommended dose is 0.4- to 0.8mg, IV, repeat if needed at 2-3 min intervals. Consider over dosage with other drugs if there is no response after a total of 10 mg has been given.
How it should be taken : 
It is usually given as an injection by a doctor or hospital staff.
Special Instruction : 
*It may make you drowsy. Do not drive a car or operate machineries while taking this medication.
*Caution needed for patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated), pregnancy and breastfeeding.
Side Effects : 
Adverse effects with naloxone occur when it is given to postoperative patients or due to sudden reversal of opioid depression or sudden withdrawal in opioid dependence.
Potentially Fatal- Severe cardiopulmonary effects in postoperative patients, most frequently in those with preexisting heart disease.
Heart- Fluid accumulation in the lungs, cardiac arrest or failure, fast heart rate.
Gastrointestinal- Vomiting, nausea.
Central Nervous System- Convulsions, tingling, agitation, hallucination, tremulousness.
Respiratory - Difficulty in breath, respiratory depression.
Skin - Injection site reactions, sweating.
Other Precautions : 
*Do not change the dosage without your doctor's advice.
Storage Conditions : 
Injection: Store it at room temperature (25°C). Protect from light.

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