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Nadroparin

Latest prescription information about Nadroparin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Nadroparin
Pronunciation : na-droe-PARE-in
Therapeutic Classification : Anticoagulants / Antithrombotics
ICD Code : Y44.2
Trade Name(s): 
India- Cardioparin Vial, Fraxiparine Pf-Syringe, Fraxodi Pf-Syringe, Nadrohep 2850 Iu Pf-Syringe, Nadrohep 3800 Iu Pf-Syringe, Nadroparin Vial.
International- Fraxiparine, Fraxiparine Forte.
Why it is prescribed (Indications) : 
This medication is a low molecular weight heparin, prescribed for venous thromboembolism, pulmonary embolism and unstable angina.  
When it is not to be taken (Contraindications): 
Contraindicated in patients with history of abnormal decrease in platelet counts, uncontrolled high blood pressure, increased risk of bleeding, peptic ulceration, head injuries, stroke. It should not be administered by the IM route.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Unstable Angina: Adults: The dose is based on body weight. It is usually 86 anti-factor Xa International Units (IU) per kilogram (kg) (39.1 anti-factor Xa IU per pound) of body weight injected under the skin every twelve hours for six days.
Venous thromboembolism and Pulmonary Embolism:
Adults: The dose is usually 2850 anti-factor Xa IU injected under the skin once a day beginning two to four hours before surgery and continuing for at least seven days.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider under the skin.
Warnings and Precautions : 
* Caution should be exercised in patients undergoing epidural anesthesia, history of heparin-induced platelet defects, increased risk of bleeding, severe liver or kidney disease, any allergy, during pregnancy and breastfeeding.
* Monitor signs of bleeding and potassium level in blood.
Side Effects : 
Most Common- Injection site blood clot, bruising, pain at injection site, decrease in platelets, nosebleed and blood in urine/stool.
Other Precautions : 
*Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15-30°C). Do not freeze or refrigerate.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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