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Nabumetone

Latest prescription information about Nabumetone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Nabumetone
Pronunciation : nab-UE-me-tone
Therapeutic Classification : analgesics
Trade Name(s): 
India- Nabuflam Tab , Nilitis Tab , Niltis Tab.
International- Relafen.
Why it is prescribed (Indications) : 
This medication is a nonsteroidal anti-inflammatory agent(NSAIA), used to treat pain and inflammation associated with muscle, bone and joint disorders such as rheumatoid arthritis and osteoarthritis.

When it is not to be taken (Contraindications): 


Active peptic ulceration; severe liver impairment; patients in whom other NSAIDs or aspirin are likely to induce asthma, severe allergic reactions, pregnancy (3rd trimester), nursing mothers, perioperative pain during heart bypass (CABG).

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Adult: Oral- 1 g as a single dose in the evening, followed by 0.5-1 g in the morning if needed.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Special Instruction : 
*Caution should be exercised in patients with history of pre-existing cardiovascular risk factors or disease; fluid retention, high blood pressure, digestive tract ulcers, elderly or debilitated patients, other forms of asthma, liver disease.
* It could cause heart attack and stroke especially in patients already at a risk.
*Closely monitor patients with any abnormal liver function test, and kidney disease. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.
Side Effects : 
Most Common- Diarrhea, dyspepsia, and abdominal pain.
Gastrointestinal- Gastritis, gastrointestinal ulcers and bleeding, Constipation, flatulence, nausea, , dry mouth, difficulty in swallowing , mouth ulcer, vomiting, altered appetite, liver function abnormalities including liver failure.
Central Nervous System- Dizziness, headache, fatigue, increased sweating, sleeplessness, nervousness, drowsiness, weakness, agitation, anxiety, confusion, depression, tingling, tremor, fainting.
Skin- Mild to severe allergic reactions, increased sensitivity to light.
Heart- Inflammation of blood vessels. It could increase the incidence of heart attack and stroke.
Respiratory- Difficulty in breathing, lung inflammation.
Genitourinary- Decrease in kidney function, , kidney failure, vaginal bleeding.
Eye and ENT- Ringing in the ear, abnormal vision.
Blood- Decrease in platelets.
Metabolic- Weight gain.
Miscellaneous- Swelling of the leg.
Hypersensitivity- Serious allergic reactions which lead to death.
Other Precautions : 
*Do not take aspirin while using this medication.
Storage Conditions : 
Oral: Store it at room temperature (20-25°C). Store it in an airtight container, and keep away from children.

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