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Mitotane

Latest prescription information about Mitotane. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Mitotane
Pronunciation : mye' toe tane
Therapeutic Classification : Chemotherapy
Trade Name(s): 
International- Lysodren.
Why it is prescribed (Indications) : 
This medication is an anti-cancer agent, prescribed for adrenal cortical cancer which is not treated with surgery. It slows growth or reduces the size of the tumor.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

When it is to be taken : 
Initially 2 to 6 g/day orally in divided doses, 3 or 4 times daily. Increase it up to 9 to 10 g/day. The maximum dose is 16 g/day.
How it should be taken : 
It comes as a tablet to take by mouth (orally). It is usually taken three to four times a day with or without food.
Special Instruction : 
*It may cause drowsiness or dizziness. Do not drive a car or operate machinery while taking this medication.
*Monitor adrenal functions, neurological and behavioral signs.
*Avoid using in children.
Side Effects : 
Heart- Hypertension, sudden fall in blood pressure, flushing.
Central Nervous System- Lethargy, drowsiness, dizziness, vertigo.
Skin- Skin toxicity.
Eye- Non-inflammatory disease of the retina, visual blurring, double vision.
Gastrointestinal-Loss of appetite, nausea, vomiting, diarrhea.
Genitourinary- Blood in urine, inflammation of the bladder, albumin is present in the urine.
Miscellaneous- Generalized aching, extreme elevation of body temperature.
Other Precautions : 
*After trauma or severe shock, stop the medication.
Storage Conditions : 
Store at 77 degrees F (25 degrees C). Store it in an airtight container and keep away from children.

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