Trade Names/Brand Names :
Why it is prescribed :
This medication is a cholesterol-reducing agent (oligonucleotide inhibitor- an orphan drug), prescribed for hypercholesterolemia.
When it is not to be taken (Contraindications):
Contraindicated in patients with moderate or severe liver impairment, and known hypersensitivity.
Category B :
Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.
Dosage & When it is to be taken (Indications):
SC- The recommended dose is 200 mg once weekly.
How it should be taken :
It comes as a solution for injection to be administered by a healthcare provider under the skin.
Warnings and Precautions :
• Caution should be exercised in patients with history of kidney or liver problems, alcoholism, any allergy, who are taking other medications, during pregnancy and breastfeeding.
Monitor blood cholesterol level regularly while taking this medication.
Side Effects :
• Most Common
Injection site reactions, flu-like symptoms, nausea, headache and elevations in serum transaminases.
Chest pain, palpitations, high blood pressure.
Vomiting, abdominal pain.
Abnormal liver function and elevation in liver enzymes.
Fatigue, fever, chills, swelling in the extremities, musculoskeletal pain, and sleeplessness.
Other Precautions :
Avoid excess dosage.
Storage Conditions :
Store it in a refrigerator (2°C to 8°C).