Metolazone - Drug Information

Generic Name : Metolazone | Pronunciation : me tole' a zone
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Latest prescription information about Metolazone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics
Drug Information

Trade Name(s): 

India : 

International : 


Why it is prescribed : 

This medication is a quinazoline diuretic, prescribed for high blood pressure. It helps the kidneys to ged rid of unwanted water and salt from the body into the urine.

When it is not to be taken (Contraindications): 

Contraindicated in patients with anuria (absence of urination), liver damage, and hypersensitivity.

Pregnancy Category :






Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

Dosage & When it is to be taken (Indications): 

PO- Adults- The recommended dose range is 2.5 – 10 mg/day.

How it should be taken : 

It comes as a tablet to take by mouth, with food.

Warnings and Precautions : 

Caution should be exercised in patients with history of lupus, kidney or liver disease, low blood mineral levels, gout, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness, dizziness, blurred vision or lightheadedness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid exposure to sunlight.
Monitor liver function, kidney function, and complete blood cell counts regularly while taking this medication.

Side Effects : 

- Cold extremities, swelling, low blood pressure and palpitations.

   Central Nervous System
- Anxiety, depression, dry mouth, impotence, nervousness, weakness and “weird” feeling.

- Itching, rash and skin dryness.

   Eyes, Ears, Nose, Throat
- Cough, nose bleed, eye itching, sinus congestion, sore throat and ringing in the ears.

- Abdominal discomfort (pain, bloating), bitter taste, constipation, diarrhea, nausea and vomiting.

- Night-time urination.

- Back pain.

Other Precautions : 

Avoid excess dosage.

Storage Conditions : 

Store it at controlled room temperature (25°C).


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