Metolazone - Drug Information

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General Information on Metolazone

Generic Name : Metolazone

Pronunciation : me tole' a zone

Latest prescription information about Metolazone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics

Why is Metolazone Prescribed? (Indications)

This medication is a quinazoline diuretic, prescribed for high blood pressure. It helps the kidneys to ged rid of unwanted water and salt from the body into the urine.

When should Metolazone not to be taken? (Contraindications)

Contraindicated in patients with anuria (absence of urination), liver damage, and hypersensitivity.

Pregnancy Category

A B C D X

Category D :

There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.

What is the dosage of Metolazone?

PO- Adults- The recommended dose range is 2.5 – 10 mg/day.

How should Metolazone be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Metolazone?

• Caution should be exercised in patients with history of lupus, kidney or liver disease, low blood mineral levels, gout, any allergy, who are taking other medications, during pregnancy and breastfeeding.
• It may cause drowsiness, dizziness, blurred vision or lightheadedness, do not drive a car or operate machinery while taking this medication.
• Avoid alcohol consumption.
• Avoid exposure to sunlight.
• Monitor liver function, kidney function, and complete blood cell counts regularly while taking this medication.

What are the side effects of Metolazone?

•   Heart : Cold extremities, swelling, low blood pressure and palpitations.
•   Central Nervous System : Anxiety, depression, dry mouth, impotence, nervousness, weakness and “weird” feeling.
•   Skin : Itching, rash and skin dryness.
•   Eyes, Ears, Nose, Throat : Cough, nose bleed, eye itching, sinus congestion, sore throat and ringing in the ears.
•   Gastrointestinal : Abdominal discomfort (pain, bloating), bitter taste, constipation, diarrhea, nausea and vomiting.
•   Genitourinary : Night-time urination.
•   Musculoskeletal : Back pain.

What are the other precautions for Metolazone?

Avoid excess dosage.

What are the storage conditions of Metolazone?

Store it at controlled room temperature (25°C).

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