This medication is a gastrointestinal stimulant and antinauseant, prescribed for heartburn and esophagitis due to GERD and for treating patients who have gastroparesis (partial paralysis of the stomach) and prevention of nausea and vomiting associated with cancer chemotherapy.
Contraindicated in patients with pheochromocytoma, bleeding, blockage, or perforation in stomach or intestines; and hypersensitivity.
Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime.
Nausea and vomiting associated with emetogenic cancer chemotherapy:
Adults: IV- 2 mg/kg by infusion 30 min before chemotherapy, repeated every 2 hours for 2 doses, then every 3 hours for 3 doses.
It comes as a tablet, an orally disintegrating (dissolving) tablet, and a solution (liquid) to take by mouth. It is usually taken 4 times a day on an empty stomach, 30 minutes before each meal and at bedtime. Injection is administered by health care providers into the vein.
• Caution needed for children, elderly, patients with history of liver or kidney disease, porphyria (group of inherited or acquired disorders of certain enzymes), epilepsy, Parkinson's disease, diabetes, history of depression.
• It may cause dizziness. Do not drive a car or operate machinery until you know how this medication affects you.
• Do not drink alcohol or use medicines that may cause drowsiness.
• Do not take more than the recommended dose or use this medication for longer than 12 weeks without checking with your doctor.
• Avoid prolong usage of this medication, otherwise it may lead to involuntary movements.
Acute heart failure, slow heart rate, fluid retention, high blood pressure, low blood pressure and fast heart rate.
• Central Nervous System: Sedation, dizziness, restlessness, involuntary body movements, spasms, depression, malignant neuroleptic syndrome (condition where patient experiences rigidity, decreased consciousness, fever and fluctuating blood pressure and heart rate – may be fatal).
• Gastrointestinal: Bowel disturbances, primarily diarrhea and nausea.
• Skin: Transient flushing of face or upper body with high IV doses.
• Hormone: Galactorrhea ( spontaneous flow of milk from the breast), breast enlargement in men and increase in serum prolactin.
• Genitourinary: Absence of a menstrual period, elevation of aldosterone, fluid retention, impotence, incontinence and urinary frequency.
• Liver: Liver toxicity (rare).
• Blood: Decrease in white blood cells and changes in hemoglobin.
• Hypersensitivity: Rapid swelling of dermis, including glossal or laryngeal edema (rare), rash and itching.
• Miscellaneous: Visual disturbances.
Insulin dosage or timing of dosage may require adjustment for diabetes patients.
Injection: Store it at 25°C. Store it in an airtight container and protect from light.
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