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Methylnaltrexone Bromide

Latest prescription information about Methylnaltrexone Bromide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Methylnaltrexone Bromide
Pronunciation : METH-il-nal-TREX-one
Therapeutic Classification : Laxatives
ICD Code : Y53.4
Trade Name(s): 
International- Relistor.
Why it is prescribed (Indications) : 
This medication is a mu-opioid receptor antagonist, prescribed for constipation caused by opioid medicines. It works by decreasing the effect of opioid medicines in the stomach.
When it is not to be taken (Contraindications): Contraindicated in patients with known or suspected stomach obstruction.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
SC- The recommended dose is 8 mg for patients weighing 38 to less than 62 kg.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider under the skin.
Warnings and Precautions : 
* Caution should be exercised in patients with history of kidney or liver disease, nausea, vomiting, stomach pain, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Abdominal pain, flatulence, nausea, dizziness, diarrhea, excessive sweating.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (20-25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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