Generic Name : Methyldopa Pronunciation : meth ill doe' pa Therapeutic Classification : Anti- Adrenergic Blockers - Centrally Acting ICD Code : Y51.8
India- Aldopam Ta, Alphadopa , Dopagyt, Emdopa, Gynapres, Sembrina.
International- Aldochlor 250, Aldoril. Why it is prescribed (Indications) : This medication is an alpha-2 receptor agonist, prescribed for hypertension. It reduces elevated blood pressure by dilating blood vessels. When it is not to be taken (Contraindications): Contraindicated in patients with liver disease, on therapy with monoamine oxidase (MAO) inhibitors, and hypersensitivity.
Dosage & When it is to be taken : Adult- The usual initial dose is 250 mg two or three times a day in the first 48 hours. Maintenance: 500mg to gm in divided doses.
Child- Initial dosage is based on 10 mg/kg of body weight daily in two to four doses. How it should be taken : It comes as a tablet and liquid to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with history of anemia, liver, kidney disease, tumor in adrenal glands, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.
* It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
* It should not be used in children. Side Effects :
Heart - Aggravation of chest pain, heart failure, sinus hypersensitivity, low blood pressure, swelling or weight gain and slow heart rate.
Gastrointestinal - Inflammation of intestine/pancreas/ mouth, vomiting, diarrhea, sore or "black" tongue, nausea, constipation, distension, flatulence and dryness of mouth.
Blood - Bone marrow depression.
Liver - Liver inflammation, jaundice and abnormal liver function.
Hypersensitivity - Inflammation of heart muscle, blood vessels, lupus-like syndrome, drug-related fever and eosinophilia.
Central Nervous System - Parkinson’s disease, Bell's palsy, decreased mental acuity, involuntary movements, mild psychoses or depression, headache, sleepiness, weakness, dizziness, lightheadedness and tingling.
Metabolic - Rise in Blood Urea Nitrogen.
Musculoskeletal - Joint pain/swelling and muscle pain.
Respiratory - Nose stuffiness.
Skin - Skin damage and rash.
Genitourinary - Absence of menstrual periods, breast enlargement in male, spontaneous secretion of milk, impotence and decreased libido.
* Avoid excess dosage. Storage Conditions :
Store it in a well-closed container at controlled room temperature (15-30°C).
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