Methotrexate - Drug Information

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General Information on Methotrexate

Generic Name : Methotrexate

Pronunciation : meth'' oh trex' ate

Latest prescription information about Methotrexate. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.4 | Therapeutic Classification : Antirheumatics

Other Name(s) of Methotrexate


Other Name : 

Amethopterin

Why is Methotrexate Prescribed? (Indications)

This medication is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta). It is also used in other cancers like blood, breast and lung cancers. It is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis. 

When should Methotrexate not to be taken? (Contraindications)

It should not be administered during breast feeding. It should also not be used in patients allergic to the drug, pregnancy, liver disease, in alcoholics, people with low blood counts or decreased immunity.

Pregnancy Category

A B C D X

Category B :

Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

What is the dosage of Methotrexate?

Oral Burkitt's lymphoma- 10-25 mg/day for 4-8 days, repeat after 7-10 days.
Oral & IMChoriocarcinoma(Ectopic Pregnancy)- 15-30 mg/day for 5 days, repeat after an interval of at least 1 week for 3-5 courses.
Mycosis fungoides- 2.5-10 mg/day to induce remission.
Rheumatoid arthritis- 7.5 mg once weekly, adjust if needed. Up to 20 mg/wk.
Crohn's disease- 12.5-22.5 mg once weekly for up to 1 year.
PO/IV/IM- Psoriasis- 10-25 mg once wkly, adjust subsequent doses if needed.
IV- Osteosarcoma- 12-15 g/m2 as infusion, followed by folinic acid.
Breast cancer 10-60 mg/m2 often with cyclophosphamide and fluorouracil. Advanced lymphosarcoma Up to 30 mg/kg, followed by folinic acid rescue. Acute lymphoblastic leukaemia Maintenance: 2.5 mg/kg every 14 days.

How should Methotrexate be taken?

It comes as a tablet to take by mouth, with or without food.It also comes as a solution for injection to be administered by a healthcare provide into a large muscle.

What are the warnings and precautions for Methotrexate?

Caution should be exercised in patients with liver or kidney problems, blood disorders, diarrhea, and stomach problems.
If vomiting or diarrhea occurs, you will need to take care not to become dehydrated.
It may cause liver or kidney impairment, bone marrow depression, ulcerative disorders of the GI tract.
Avoid become pregnant while taking this medication.
Monitor hematological, renal and hepatic function and GI toxicity regularly.
Avoid drinking alcohol while you are taking this medication.

What are the side effects of Methotrexate?

  Central Nervous System: Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.
  Skin: Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions.
  Eye and ENT: Blurred vision, inflammation of the gums, inflammation of pharynx.
  Gastrointestinal: Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding.
  Genitourinary: Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.
  Blood: Deficiency of all three blood cell types, bone marrow depression, anemia, bleeding, presence of bacteria in the blood (septicemia).
  Liver: Elevated LFTs (liver function test), liver damage.
  Respiratory: Deaths from interstitial pneumonia, chronic interstitial obstructive lung disease.
  Miscellaneous: Malaise, chills, fever, lower resistance to infections, joint pain, muscle pain, diabetes, osteoporosis, allergic reactions, sudden death.

What are the other precautions for Methotrexate?

Do not take medicines containing aspirin, ibuprofen or folic acid while taking this medication.

What are the storage conditions of Methotrexate?

Store intact vials at room temperature (15-25�C). Keep this medication in an airtight container.

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gopal-agrawal 

whether iron tabs/B Complex along side Oncotrex tabs can be taken?

mdnimkar 

Is this drug really useful for psoriasis?Since the drug denotes the name related to cancer,why is it recommended for psoriasis?If any patient is under medication of aspirin,should he stop taking the aspirin?If stopped,who is responsible for the complications arising out of this?

jaichand 

If these are the side effects of this Drug Methotrexate , why it is prescribed for psoriasis?. Does Doctor community want to make money or Bribed by Pharma Drug companies to Sell this?.

rajumar78 

AM RAM,34 YEARS OLD,MALE AND GOT MARRIED.STILL THERE IS NO ISSUE TO ME.AM UNDER GOING TREATMENT FOR PSORIASIS ALSO.IN THIS SITUATION,CAN I TAKE ONCOTREX 7.5?IS IT LEAD TO INFERTILITY PROBLEM TO MY WIFE???KINDLY ADVICE>>>

Amlan Mukherjee 

My wife is suffering from moderate to severe Psoriasis problem. After 3 weeks of treatment with ointment doctor prescribed this medicine, twice together for 6 weeks. Does it have severe side effects and is it necessary at this stage when the problem is coming down. All blood tests done and report is clear.

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