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Methimazole

Latest prescription information about Methimazole. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Methimazole
Pronunciation : meth im' a zole
Therapeutic Classification : Thyroid and Antithyroid Agents
ICD Code : Y42.2
Trade Name(s): 
India- Methimez .
International- Mercazole, Thyrozole.
Why it is prescribed (Indications) : This medication is an antithyroid agent, prescribed for hyperthyroidism. It works by inhibiting the production of thyroid hormone.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: The initial daily dosage is 15 mg. It may be increased upto 60 mg, divided into 3 doses at 8-hour intervals. The maintenance dosage is 5 to 15 mg daily.
Pediatric: Initially, the daily dosage is 0.4 mg/kg, divided into 3 doses and given at 8-hour intervals.
How it should be taken : It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of decrease in blood cells, liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause drowsiness, dizziness, or lightheadedness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Skin - Rash, hives, abnormal loss of hair, itching and skin pigmentation.
Gastrointestinal - Nausea, vomiting and stomach upset.
Musculoskeletal - Joint/muscle pain.
Central Nervous System - Tingling, headache, drowsiness, dizziness and fainting.
Miscellaneous - Loss of taste, swelling and jaundice.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15° to 30°C), and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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