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Mestranol and Norethindrone

Latest prescription information about Mestranol and Norethindrone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Mestranol and Norethindrone
Pronunciation : MES-tra-nole- nor-eth-IN-drone
Therapeutic Classification : Contraceptives
Trade Name(s): 
International- Norinyl 1 + 50 and Ortho-Novum 1/50.
Why it is prescribed (Indications) : This medication is a combination of 2 hormones namely estrogen and progestogen, used as an oral contraceptive to prevent pregnancy.  It causes changes in cervical mucus and uterine lining, making it harder for sperm to reach the uterus.
When it is not to be taken (Contraindications): Contraindicated in patients with breast cancer, uterine cancer or unexplained vaginal bleeding, stroke, blood clots, heart attack or chest pain, liver impairment, hypersensitivity and pregnancy.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Dosage & When it is to be taken : For a 28 day package, one tablet is taken daily for 28 days and a new package begun on the following day. For a 21-day package, one tablet is taken daily for 21 days followed by 7 days with no medication.
How it should be taken : It comes as a tablet to take by mouth as directed by your physician.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart disease, high cholesterol, high blood pressure, depression, diabetes, gallbladder disease, epilepsy, irregular menstrual periods, liver or kidney impairment, obesity, smokers, varicose veins, women aged over 35 years, children and breastfeeding.
* Avoid smoking while taking this medication; otherwise it may increase the risk of stroke, heart attack, blood clots and high blood pressure.
* Do not miss the dosage.
* Avoid sharing of injection or needles with others.
Side Effects : 
Most Common- Nausea, vomiting, breast tenderness, vaginal infection, spotting, weight changes and headache.
Genitourinary- Irregular periods.
Central Nervous System - Breast enlargement, decreased sex drive, vaginal itching or discharge, depression, confusion, headache, weakness, speech disorder, nervousness, dizziness and tiredness.
Gastrointestinal- Stomach cramps, bloating and loss of appetite.
Miscellaneous- Jaundice, dark urine, shoulder pain and sweating.
Other Precautions : 
* Monitor blood sugar level regularly while taking this medication.
Storage Conditions : 
Store it at room temperature and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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