This medication is an antimetabolite, prescribed for acute lymphatic leukemia either alone or with other medications. It works by stopping the growth of cancer cells.
Contraindicated in patients who have prior resistance to this drug, and hypersensitivity.
Adult: PO- Acute lymphatic Leukemia: Usual maintenance dose: Initial: 1.5-2.5 mg/kg/day, may increase carefully up to 5 mg/kg/day.
Crohn's disease Initial: 1-1.5 mg/kg/day. Up to 125 mg/day.
It comes as a tablet to take by mouth, on an empty stomach.
• Caution should be exercised in patients with history of bone marrow problems, anemia, low white blood cell or platelet levels, unusual bruising or bleeding, liver or kidney problems, infections, any allergy, during pregnancy and breastfeeding.
• Avoid contact with people who have infections.
• It may reduce platelet counts; to prevent bleeding avoid injury or bruising.
• Patient may develop with increased risk other than cancer; if any unusual tumor appears consult with your doctor immediately.
• Avoid vaccination while taking this medication.
• Monitor blood cell counts, liver function tests, and TPMT enzyme activity regularly while taking this medication.
• Serious Effects :
Bone marrow depression and liver damage.
• Genitourinary : Abnormally elevated blood level of uric acid.
• Gastrointestinal : Intestinal ulceration, nausea, vomiting, and loss of appetite.
• Miscellaneous : Hair loss and decrease in sperm count.
Avoid excess dosage.
Store it at controlled room temperature (15° to 25°C).
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