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Mephobarbital

Latest prescription information about Mephobarbital. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Mephobarbital
Pronunciation : me-foe-BAR-bih-tal
Therapeutic Classification : Anticonvulsants
ICD Code : Y47.0
Trade Name(s): 
International- Mebaral.
Why it is prescribed (Indications) : 
This medication is a barbiturate, prescribed for anxiety, tension, apprehension, and preventing seizures. It works by restoring the balance of neurotransmitters in the brain.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Epilepsy: Average dose for adults: 400 mg to 600 mg (6 grains to 9 grains) daily; children under 5 years: 16 mg to 32 mg (1/4 grain to ½ grain) three or four times daily.
Sedation: Adults: 32 mg to 100 mg (½ grain to 1 ½ grains)–optimum dose, 50 mg (3/4 grain)–three to four times daily. Children: 16 mg to 32 mg (1/4 grain to ½ grain) three to four times daily.
How it should be taken : 
It comes as a tablet, to take by mouth with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of kidney or liver problems, suicidal thoughts, lung disease, heart disease, depression, who are taking other medications, any allergy, during pregnancy and breastfeeding.
* It may cause dizziness, drowsiness, or lightheadedness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption while taking this medication.
* Monitor blood cell counts and kidney and liver function tests regularly while taking this medication.
Side Effects : 
Most Common - Drowsiness.
Central Nervous System - Agitation, confusion, incoordination, CNS depression, abnormal dreams, nervousness, psychiatric disturbances, hallucinations, sleeplessness, anxiety, dizziness, thinking abnormality.
Respiratory - Difficulty in breathing.
Heart - Slow heart rate, low blood pressure, and fainting.
Gastrointestinal - Nausea, vomiting, constipation.
Others - Headache, hypersensitivity reactions such as angioedema, skin rashes; fever, liver damage, anemia.
Other Precautions : 
* Avoid excess dosage
Storage Conditions : 
Store the medication as directed by your physician.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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