Meperidine - Drug Information

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General Information on Meperidine

Generic Name : Meperidine

Pronunciation : me per' i deen

Latest prescription information about Meperidine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45 | Therapeutic Classification : Analgesics

Trade Names/Brand Names of Meperidine

India- Pethidine HCL vial.
International- Demerol Hydrochloride.

Other Name(s) of Meperidine


Other Name : 

Pethidine

Why is Meperidine Prescribed? (Indications)

This medication is a narcotic analgesic, prescribed for moderate to severe pain. 

When should Meperidine not to be taken? (Contraindications)

Contraindicated in patients with severe respiratory insufficiency, certain type of intestinal inflammation, and hypersensitivity; who are taking or who have recently taken monoamine oxidase (MAO) inhibitors.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Meperidine?

Adults: The usual dosage is 50 mg to 150 mg orally, every 3 or 4 hours as necessary.
Pediatric Patients: The usual dosage is 1.1 mg/kg to 1.8 mg/kg orally, upto the adult dose, every 3 or 4 hours as necessary.

How should Meperidine be taken?

It comes as a tablet and syrup (liquid) to take by mouth with or without food.
It also comes as a solution for injection to be administered by a healthcare provider into the vein, muscle or under the skin.

What are the warnings and precautions for Meperidine?

Caution should be exercised in patients with history of Addison's disease, head injury, mental illness, asthma, chronic obstructive pulmonary disease (COPD), sickle cell anemia, pheochromocytoma (a type of tumor), enlarged prostate gland, urinary obstruction, irregular heartbeat, seizures, stomach problems, thyroid, liver, kidney or lung disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause drowsiness, dizziness, or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
Avoid alcohol consumption.
Avoid long-term use of this medication; otherwise patient may get addicted to this drug.

What are the side effects of Meperidine?

   Severe effects : Respiratory depression, poor blood circulation, shock and heart arrest.
   Central Nervous System : Emotion, anxiety, weakness, headache, agitation, tremor, uncoordinated muscle movements, convulsions, transient hallucinations and disorientation and visual disturbances.
   Gastrointestinal : Dry mouth, constipation and biliary tract spasm.
   Heart : Flushing of the face, fast/slow heart rate, palpitation, low blood pressure and fainting.
   Genitourinary : Urinary retention.
   Allergic reactions : Itching, hives and rash.

What are the other precautions for Meperidine?

Avoid excess dosage.

What are the storage conditions of Meperidine?

Store it at room temperature (25 C), and in an airtight container. Keep away from children.

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