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Meperidine

Latest prescription information about Meperidine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Meperidine
Pronunciation : me per' i deen
Therapeutic Classification : Analgesics
ICD Code : Y45
Trade Name(s): 
India- Pethidine HCL vial.
International- Demerol Hydrochloride.
Other Name : Pethidine
Why it is prescribed (Indications) : 
This medication is a narcotic analgesic, prescribed for moderate to severe pain. 
When it is not to be taken (Contraindications): Contraindicated in patients with severe respiratory insufficiency, certain type of intestinal inflammation, and hypersensitivity; who are taking or who have recently taken monoamine oxidase (MAO) inhibitors.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adults: The usual dosage is 50 mg to 150 mg orally, every 3 or 4 hours as necessary.
Pediatric Patients: The usual dosage is 1.1 mg/kg to 1.8 mg/kg orally, upto the adult dose, every 3 or 4 hours as necessary.
How it should be taken : It comes as a tablet and syrup (liquid) to take by mouth with or without food.
It also comes as a solution for injection to be administered by a healthcare provider into the vein, muscle or under the skin.
Warnings and Precautions : 
* Caution should be exercised in patients with history of Addison's disease, head injury, mental illness, asthma, chronic obstructive pulmonary disease (COPD), sickle cell anemia, pheochromocytoma (a type of tumor), enlarged prostate gland, urinary obstruction, irregular heartbeat, seizures, stomach problems, thyroid, liver, kidney or lung disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause drowsiness, dizziness, or lightheadedness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
* Avoid alcohol consumption.
*Avoid long-term use of this medication; otherwise patient may get addicted to this drug.
Side Effects : 
Severe effects - Respiratory depression, poor blood circulation, shock and heart arrest.
Central Nervous System - Emotion, anxiety, weakness, headache, agitation, tremor, uncoordinated muscle movements, convulsions, transient hallucinations and disorientation and visual disturbances.
Gastrointestinal - Dry mouth, constipation and biliary tract spasm.
Heart - Flushing of the face, fast/slow heart rate, palpitation, low blood pressure and fainting.
Genitourinary - Urinary retention.
Allergic reactions - Itching, hives and rash.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (25° C), and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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