This medication is a chemotherapy agent, prescribed for multiple myeloma, melanoma, and ovarian carcinoma. It stops or slows the growth of cancer cells in the body.
Contraindicated in patients with severe bone marrow suppression and hypersensitivity.
PO- Multiple Myeloma: The usual oral dose is 6 mg (3 tablets) daily. The entire daily dose may be given at one time.
Epithelial Ovarian Cancer: dose of 0.2 mg/kg daily for 5 days as a single course. Melanoma: 0.6-1 mg/kg.
It comes as a tablet to take by mouth, on an empty stomach. It also comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with history of bone marrow depression, infection, low white blood cell count, kidney problems, shingles, chickenpox, under going radiation therapy, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
• Avoid contact with people who have infections.
• It may affect platelet counts; to prevent bleeding avoid injury or bruising.
• Monitor complete blood counts regularly while taking this medication.
• Most common :
Bone marrow suppression.
• Gastrointestinal : Nausea, vomiting, diarrhea and oral ulceration.
• Liver : Abnormal liver function, jaundice and liver inflammation.
• Miscellaneous : Lung scar, lung inflammation, skin hypersensitivity, rash, inflammation of blood vessels, hair loss and anemia.
• Allergic reactions : Hives, swelling, and rarely shock.
Avoid excess dosage.
Store it in the refrigerator (2° to 8°C), and keep away from children.
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