Lubiprostone - Drug Information

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General Information on Lubiprostone

Generic Name : Lubiprostone

Pronunciation : LOO-bi-PROST-one

Latest prescription information about Lubiprostone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y53.4 | Therapeutic Classification : Laxatives

Trade Names/Brand Names of Lubiprostone

India : 

International : 

Amitiza

Why is Lubiprostone Prescribed? (Indications)

This medication is a chloride channel activator, prescribed for chronic constipation and irritable bowel syndrome. It increases the amount of fluid that flows into the bowel and allowing the stool to pass more easily.

When should Lubiprostone not to be taken? (Contraindications)

Contraindicated in patients with gastrointestinal obstruction, and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Lubiprostone?

The recommended dose is 24 mcg twice daily orally with food and water.

How should Lubiprostone be taken?

It comes as a capsule, to take by mouth, with food.

What are the warnings and precautions for Lubiprostone?

Caution should be exercised in patients with history of diarrhea, stomach or bowel blockage, who are taking other medications, any allergy, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Lubiprostone?

   Gastrointestinal : Nausea, diarrhea, abdominal pain, abdominal distension, flatulence, vomiting, loose stools, abdominal discomfort, indigestion, dry mouth and stomach discomfort.
   Central Nervous system : Headache, and dizziness.
   General : Swelling in the extremities, fatigue and chest discomfort/pain.

What are the other precautions for Lubiprostone?

Avoid excess dosage.

What are the storage conditions of Lubiprostone?

Store it at controlled room temperature (15 to 30C).

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