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Lubiprostone - Drug Information

Generic Name : Lubiprostone | Pronunciation : LOO-bi-PROST-one

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Latest prescription information about Lubiprostone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y53.4 | Therapeutic Classification : Laxatives
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Trade Name(s): 


India : 



International : 

Amitiza

Why it is prescribed (Indications) : 


This medication is a chloride channel activator, prescribed for chronic constipation and irritable bowel syndrome. It increases the amount of fluid that flows into the bowel and allowing the stool to pass more easily.

When it is not to be taken (Contraindications): 

Contraindicated in patients with gastrointestinal obstruction, and hypersensitivity.

Pregnancy Category :

A B C D X

Category C :

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Dosage & When it is to be taken : 


The recommended dose is 24 mcg twice daily orally with food and water.

How it should be taken : 


It comes as a capsule, to take by mouth, with food.

Warnings and Precautions : 

Caution should be exercised in patients with history of diarrhea, stomach or bowel blockage, who are taking other medications, any allergy, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.

Side Effects : 


   Gastrointestinal
- Nausea, diarrhea, abdominal pain, abdominal distension, flatulence, vomiting, loose stools, abdominal discomfort, indigestion, dry mouth and stomach discomfort.

   Central Nervous system
- Headache, and dizziness.

   General
- Swelling in the extremities, fatigue and chest discomfort/pain.

Other Precautions : 

Avoid excess dosage.

Storage Conditions : 

Store it at controlled room temperature (15° to 30°C).

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