Generic Name : Lopinavir and Ritonavir Pronunciation : loe pin' a veer- ri toe' na veer Therapeutic Classification : Antiretroviral Agents ICD Code : Y41.5
International- Kaletra and Aluvia. Why it is prescribed (Indications) :
This combination medication contains antiretroviral agents, prescribed for HIV-1 infection. It works by decreasing the amount of HIV in the blood. When it is not to be taken (Contraindications):
It should not be co-administered with highly dependent on CYP3A(a gene) for clearance and HMG-CoA Reductase inhibitors. Contraindicated in patients with known hypersensitivity.
Dosage & When it is to be taken :
PO- The recommended dose is 200/50 tablets, two twice daily or four, once daily; Oral solution, 5 mL twice daily or 10 mL once daily with food. How it should be taken :
It comes as a tablet to take by mouth, with or without food. Warnings and Precautions :
* Caution should be exercised in patients with history of QT prolongation, irregular heartbeat, decrease in blood minerals, hemophilia, high cholesterol, swelling of the pancreas, heart or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* Monitor cholesterol and triglyceride levels, viral load, and liver function regularly while taking this medication.
* It does not stop the spread of infection to others; avoid sexual contact, sharing of needles, injection supplies. Side Effects :
Most Common - Diarrhea.
Gastrointestinal - Nausea, vomiting, abdominal pain, indigestion, flatulence.
General - Weakness.
Metabolic- Decreased weight and appetite.
Musculoskeletal - Muscle pain.
Central Nervous System - Headache, tingling, sleeplessness, depression, libido decreased.
Skin - Rash.
Heart - Dilatation of blood vessels.
* Avoid excess dosage. Storage Conditions :
Capsules and solution should be refrigerated at 2-8°C (36-46°F). If stored at room temperature, the capsules and solution should be used within 2 months.
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