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Linagliptin and Metformin Hydrochloride

Latest prescription information about Linagliptin and Metformin Hydrochloride. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Linagliptin and Metformin Hydrochloride
Pronunciation : LIN-a-GLIP-tin- met-FOR-min
Therapeutic Classification : Antidiabetics
ICD Code : Y42.3
Trade Name(s): 
International- Jentadueto.
Why it is prescribed (Indications) : 
This combination medication contains dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide, prescribed for type 2 diabetes in certain patients along with diet and exercise.  
When it is not to be taken (Contraindications): 
Contraindicated in patients with type 1 diabetes, stroke, recent heart attack, shock, severe infection, low blood oxygen levels, kidney or liver problems, and hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Dose is based on patient’s condition. The recommended dose is 2.5 mg linagliptin/1000 mg metformin hydrochloride twice daily.
How it should be taken : 
It comes as a tablet to take by mouth, with meals as directed by your doctor.
Warnings and Precautions : 
* Caution should be exercised in patients with history of heart disease, lung or breathing problems, thyroid problems, stomach problems, adrenal or pituitary problems, lactic acidosis, inflammation of the pancreas, gallstones, high blood cholesterol, alcohol abuse, angioedema, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* Avoid alcohol consumption.
* Monitor kidney function, fasting blood glucose, hemoglobin A1c, and complete blood cell counts regularly while taking this medication.
Side Effects : 
Cough, decreased appetite, diarrhea, gas, headache, indigestion, nausea, runny or stuffy nose, sore throat, stomach upset, vomiting, and weakness.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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