Leucovorin - Drug Information

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General Information on Leucovorin

Generic Name : Leucovorin

Pronunciation : loo-koh-VOR-in

Latest prescription information about Leucovorin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y51.1 | Therapeutic Classification : Cholinergic Agents

Other Name(s) of Leucovorin


Other Name : 

Folinic acid, citrovorum factor, 5-formyl tetrahydrofolate.

Why is Leucovorin Prescribed? (Indications)

This medication is a folic acid analog, prescribed for reducing the toxic effects of methotrexate.  It works by replacing folic acid in the body.

When should Leucovorin not to be taken? (Contraindications)

Contraindicated in patients with anemia (B12 deficiency) and hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Leucovorin?

IM/IV/PO- The recommended dose is 15 mg (10 mg/m2) every 6 hours.

How should Leucovorin be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein or muscle. It also comes as a tablet to take by mouth.

What are the warnings and precautions for Leucovorin?

Caution needed for patients with history of blood problems, pleural effusion, during pregnancy and breastfeeding.

What are the side effects of Leucovorin?

Diarrhea, severe allergic reactions like rash, hives, itching, and difficulty in breathing or swallowing.

What are the other precautions for Leucovorin?

Avoid excess dosage.

What are the storage conditions of Leucovorin?

Store in refrigerated conditions (2 to 8C), protect from light and heat.

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drpoonamgupta 

nicely the important information is given here,thanks.can the detail information about its action in protection of healthy cells,be added?some doctors are adding it with methotrexate even when no overdose is expected,is there any rationale behind it?

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