Letrozole - Drug Information

Generic Name : Letrozole | Pronunciation : LET-roe-zole

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Latest prescription information about Letrozole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.3 | Therapeutic Classification : Chemotherapy
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Trade Name(s): 
India : 

International : Femara

Why it is prescribed (Indications) : 
This medication is an aromatase inhibitor, prescribed for breast cancer either alone or in combination with other medications. It kills cancer cells. 

When it is not to be taken (Contraindications): 
Contraindicated in women who have experienced with premenopause, and for children; hypersensitivity.

Pregnancy Category :

A B C D X

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


Dosage & When it is to be taken : 
The recommended dose is 2.5mg/day, orally, administered after chemotherapy for breast cancer.

How it should be taken : 
It comes as a tablet to take by mouth, with or without food.

Warnings and Precautions : Inform your doctor about severe kidney, liver problem, bone diseases.
It may make you drowsy. Do not drive a car or operate machinery until knowing its effect.
It is only for women who have experienced menopause and cannot become pregnant. Inform your doctor about your pregnancy and lactation.

Side Effects : Heart- Hypertension, chest pain, coronary heart disease, paralysis, strokes, heart attack, fluid accumulation in the lungs, vein inflammation, mini stroke and blood clot in veins.
Central Nervous System- Weakness, headache, dizziness, fatigue, sleeplessness, drowsiness, anxiety and depression.
Skin- Hot flushes, increased sweating, night sweats, rash, hair loss and itching.
Eye and ENT- Blurred vision.
Gastrointestinal- Nausea, constipation, diarrhea, vomiting, abdominal pain and loss of appetite.
Genitourinary- Breast pain, urinary tract infection, kidney disorder, vaginal bleeding and vaginal dryness.
Liver- Increased liver enzymes level.
Metabolic- High level of cholesterol in blood, increased weight and high calcium in blood.
Musculoskeletal- Joint pain, bone pain, back pain, limb pain, inflammation of joints, muscle pain, fracture and inflammation due to fracture.
Respiratory- Difficulty in breathing, cough and chest wall pain.
Miscellaneous- Swelling of leg, infections/infestations, influenza, pain and pleural effusion.

Other Precautions :  Monitor bone mineral density regularly.

Storage Conditions : Store at 25�C. Store it in air tight container and keep away from children.

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