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Lacosamide

Latest prescription information about Lacosamide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Lacosamide
Pronunciation :  la-KOE-sa-mide
Therapeutic Classification : Anticonvulsants
ICD Code : Y46.6
Trade Name(s): 
India- Lacasa.
International- Vimpat.
Why it is prescribed (Indications) : This medication is an anticonvulsant, prescribed for partial-onset of seizures. It may work by slowing abnormal nerve impulses in the brain.
When it is not to be taken (Contraindications): Contraindicated in patients with severe liver problems, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : PO/IV- The recommended initial dose should be 50 mg twice daily (100 mg per day). The recommended maintenance dose is 200 to 400 mg/day.
How it should be taken : It comes as a tablet to take by mouth, with or without food.
It also comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of sugar, nerve problems, liver, kidney impairment, who are on dialysis, mental illness, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Monitor electrocardiogram (ECG), liver or kidney function regularly while taking this medication.
Side Effects : 
Severe reactions - Dizziness, incoordination, vomiting, double vision, nausea, fainting, and blurred vision.
Eye and ENT - Inner ear damage.
Gastrointestinal - Diarrhea.
General - Fatigue, gait disturbances and weakness.
Skin - Bruising, itching, rash and skin laceration.
Central Nervous system - Headache, drowsiness, tremor, night blindness, balance disorder, memory loss and depression.
Heart- Slow heart rate.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (20° to 25°C).
♦ Safety Labeling Changes Approved By FDA

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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